Adapter protein X11beta antibody Amyloid beta A4 precursor protein-binding family A member 2 antibody APBA2 antibody APBA2_HUMAN antibody D15S1518E antibody HsT16821 antibody LIN 10 antibody MGC:14091 antibody MGC99508 antibody Mint 2 antibody Mint-2 antibody MINT2 antibody Neuron-specific X11L protein antibody Neuronal Munc18-1-interacting protein 2 antibody Phosphotyrosine binding/interacting domain (PTB) bearing protein antibody X11 beta antibody X11 like protein antibody X11l antibody
Product description
The β-Amyloid precursor protein (β-APP) is a major constituent of the amyloid deposits in patients with Alzheimer's disease. The β-Amyloid precursor is known to interact with several proteins, including X11 and the G heterotrimetric protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to the β-Amyloid precursor protein via a phosphotyrosine binding (PTB) domain, reducing the secretion of cellular β-APP and slowing β-APP processing pathways. X11 binds specifically to the YENPTY motif, which is involved in the internalization of β-APP. Multiple splice varitents of X11 have been identified, including X11α (also designated Mint 1), X11β (Mint 2) and X11γ (Mint 3).
Immunogen
Recombinant protein
Key Feature
Clonality
Monoclonal
Isotype
IgG1
Host Species
Mouse
Tested Applications
WBICC
WB:1:500-1:1,000 ICC:1:50-1:200
Species Reactivity
Human
Concentration
2mg/ml
Purification
Unpurified
Target Information
Alternative Names
Adapter protein X11beta antibody Amyloid beta A4 precursor protein-binding family A member 2 antibody APBA2 antibody APBA2_HUMAN antibody D15S1518E antibody HsT16821 antibody LIN 10 antibody MGC:14091 antibody MGC99508 antibody Mint 2 antibody Mint-2 antibody MINT2 antibody Neuron-specific X11L protein antibody Neuronal Munc18-1-interacting protein 2 antibody Phosphotyrosine binding/interacting domain (PTB) bearing protein antibody X11 beta antibody X11 like protein antibody X11l antibody
Fig1: Western blot analysis of APBA2 on human APBA2 recombinant protein using anti-APBA2 antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of APBA2 on HEK293 (1) and APBA2-hIgGFc transfected HEK293 (2) cell lysate using anti-APBA2 antibody at 1/1,000 dilution.
Application
Fig3: ICC staining APBA2 (green) and Actin filaments (red) in Hela cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Positive Control
Human APBA2 recombinant protein, APBA2-hIgGFc transfected HEK293 cell lysate, Hela.
Application Notes
WB:1:500-1:1,000 ICC:1:50-1:200
Additional Information
Form
Liquid
Storage Instructions
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
