| 存储条件 |
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| Product Name | DIS3L2 [B2-C7] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DI3L2_HUMAN antibody DIS3 L2 antibody DIS3 mitotic control homolog (S. cerevisiae) like 2 antibody DIS3 mitotic control homolog like 2 antibody DIS3-like exonuclease 2 antibody Dis3l2 antibody FLJ36974 antibody MGC42174 antibody |
| Product description | The exosome is a multisubunit complex composed of several highly conserved subunits, some of which are 3' to 5' exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich (ARE) elements in their untranslated 3' region. DIS3L2 (DIS3-like exonuclease 2) is an 885 amino acid protein that is thought to function as an exonuclease and may be required for the 3' processing of pre-mRNA into mature mRNA. Defects or chromosomal translocations involving the gene encoding DIS3L2 may be associated with Marfanoid habitus, a genetic disorder characterized by abnormalities in the skeleton, eyes and cardiovascular system. DIS3L2 is expressed as five isoforms due to alternative splicing events. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIHCFC |
| WB:1:500-1:1,000 IHC:1:50-1:200 FC:1:100-1:200 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | DI3L2_HUMAN antibody DIS3 L2 antibody DIS3 mitotic control homolog (S. cerevisiae) like 2 antibody DIS3 mitotic control homolog like 2 antibody DIS3-like exonuclease 2 antibody Dis3l2 antibody FLJ36974 antibody MGC42174 antibody |
|---|---|
| Molecular Weight(MW) | 100 kDa |
| Cellular Localization | Cytoplasm. |
| SwissProt ID | Q8IYB7 |
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Application
Fig1: Western blot analysis of DIS3L2 on human DIS3L2 recombinant protein using anti-DIS3L2 antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of DIS3L2 on HEK293 (1) and DIS3L2-hIgGFc transfected HEK293 (2) cell lysate using anti-DIS3L2 antibody at 1/1,000 dilution.
Application
Fig3: Western blot analysis of DIS3L2 on Hela (1) and HepG2 (2) cell lysate using anti-DIS3L2 antibody at 1/1,000 dilution.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissue using anti-DIS3L2 antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded human bladder cancer tissue using anti-DIS3L2 antibody. Counter stained with hematoxylin.
Application
Fig6: Flow cytometric analysis of Jurkat cells with DIS3L2 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).| Positive Control | Human DIS3L2 recombinant protein, DIS3L2-hIgGFc transfected HEK293 cell lysate, Hela and HepG2 cell lysate, human endometrial cancer tissue, human bladder cancer tissue, Jurkat. |
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| Application Notes | WB:1:500-1:1,000 IHC:1:50-1:200 FC:1:100-1:200 |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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