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| Product Name | MUC5AC [G6-H8] |
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| Antibody Type | Primary Antibodies |
| Antigen Alias | Apomucin antibody Apomucin Major Airway Glycoprotein antibody Gastric mucin antibody LeB antibody Lewis B blood group antigen antibody Major Airway Glycoprotein antibody MUC 5 antibody MUC5 antibody MUC5AC antibody Mucin 5 subtype AC tracheobronchial antibody Mucin 5 Subtypes A And C antibody Mucin 5 subtypes A and C tracheobronchial/gastric antibody Mucin 5, tracheobronchial/gastric antibody Mucin 5AC antibody Mucin 5AC oligomeric mucus/gel forming antibody Mucin 5AC, oligomeric mucus/gel forming pseudogene antibody Mucin antibody TBM antibody Tracheobronchial Mucin (TBM) antibody Tracheobronchial mucin antibody |
| Product description | Mucins are a group of high molecular weight glycoproteins consisting of a mucin core protein and O-linked carbohydrates. Mucin 6 carries GlcNAca1>4Galb>R structures, indicating that alpha1, 4-N-acetylglucosaminyltransferase is important to the formation of the mucous glycoproteins in vivo. Mucin 5AC is a gel-forming mucin that is secreted from surface mucous cells. Glucocorticoid is required for the expression of Mucin 5AC mRNA and high doses of hydrocortisone suppress its expression. Additionally, asthmatic fluid stimulates Mucin 5AC synthesis several-fold. The pro-inflammatory cytokines IL-6 and TNF-alpha stimulate Mucin 5AC secretion and thus contribute to the upregulation of mucin by chronic inflammation. Expression of Mucin 5AC is retinoic acid (RA)- or retinol- dependent and RA control of mucin genes is mediated by the retinoid acid receptor RARα and, to a lesser extent, by RARγ. Thyroid hormone binding to thyroid receptors inhibits Mucin 5AC gene expression. Mucin 5AC is also expressed in normal endocervical epithelium, small intestine, gastric cells (Lewis type 1) and gastric metaplasia, and it is a one of the major mucins in the ethmoid mucosa. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2a |
| Host Species | Mouse |
| Tested Applications | WBIHCFC |
| WB:1:500-1:2,000 IHC:1:200-1:500 FC:1:100-1:200 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | Apomucin antibody Apomucin Major Airway Glycoprotein antibody Gastric mucin antibody LeB antibody Lewis B blood group antigen antibody Major Airway Glycoprotein antibody MUC 5 antibody MUC5 antibody MUC5AC antibody Mucin 5 subtype AC tracheobronchial antibody Mucin 5 Subtypes A And C antibody Mucin 5 subtypes A and C tracheobronchial/gastric antibody Mucin 5 tracheobronchial/gastric antibody Mucin 5AC antibody Mucin 5AC oligomeric mucus/gel forming antibody Mucin 5AC oligomeric mucus/gel forming pseudogene antibody Mucin antibody TBM antibody Tracheobronchial Mucin (TBM) antibody Tracheobronchial mucin antibody |
|---|---|
| Molecular Weight(MW) | 585 kDa |
| Cellular Localization | Secreted, Cytoplasmic, cell surface. |
| SwissProt ID | P98088 |
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Application
Fig1: Western blot analysis of Mucin 5AC on human Mucin 5AC recombinant protein using anti- Mucin 5AC antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of Mucin 5AC on HEK293 (1) and Mucin 5AC -hIgGFc transfected HEK293 (2) cell lysate using anti- Mucin 5AC antibody at 1/1,000 dilution.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human stomach cancer tissues using anti- Mucin 5AC antibody. Counter stained with hematoxylin.
Application
Fig4:Immunohistochemical analysis of paraffin-embedded human stomach tissues using anti- Mucin 5AC antibody. Counter stained with hematoxylin.
Application
Fig5: Flow cytometric analysis of Hela cells with Mucin 5AC antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).| Positive Control | Human Mucin 5AC recombinant protein, Mucin 5AC -hIgGFc transfected HEK293 cell lysate, human stomach cancer, human stomach, Hela. |
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| Application Notes | WB:1:500-1:2,000 IHC:1:200-1:500 FC:1:100-1:200 |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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