| 存储条件 |
|---|
| Product Name | MSTN [B2-E4] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | GDF 8 antibody GDF-8 antibody GDF8 antibody GDF8_HUMAN antibody Growth differentiation factor 8 antibody Growth/differentiation factor 8 antibody MSLHP antibody MSTN antibody Myostatin antibody OTTHUMP00000163498 antibody |
| Product description | Growth/differentiation factors (GDFs) are members of the TGF superfamily. Members of the TGF superfamily are involved in embryonic development and adult tissue homeostasis. GDF-8, also known as myostatin, has been shown to be a negative regulator of skeletal muscle growth. GDF-11 has been shown to control anterior/posterior patterning of the axial skeleton, and also regulates kidney and pancreas organogenesis. GDF-11 controls anterior/posterior patterning of the axial skeleton, regulates organogenesis by controlling the expression of GDNF, contributes to the control of HOX gene expression and induces phosphorylation of Smad2. In addition, GDF-11 mediates signaling of Nodal during left-right patterning and development of head structures and inhibits generation of new neurons by neuronal progenitors in the olfactory epithelium. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2b |
| Host Species | Mouse |
| Tested Applications | WBIHCFC |
| WB:1:500-1:2,000 IHC:1:200-1:1,000 FC:1:50-1:100 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | GDF 8 antibody GDF-8 antibody GDF8 antibody GDF8_HUMAN antibody Growth differentiation factor 8 antibody Growth/differentiation factor 8 antibody MSLHP antibody MSTN antibody Myostatin antibody OTTHUMP00000163498 antibody |
|---|---|
| Molecular Weight(MW) | 43 kDa |
| Cellular Localization | Secreted |
| SwissProt ID | O14793 |
|---|
Application
Fig1: Western blot analysis of GDF8 on human GDF8 recombinant protein using anti- GDF8 antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of GDF8 on LNcap cell lysate using anti- GDF8 antibody at 1/1,000 dilution.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue using anti- GDF8 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti- GDF8 antibody. Counter stained with hematoxylin.
Application
Fig5: Flow cytometric analysis of LNcap cells with GDF8 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).| Positive Control | Human GDF8 recombinant protein, LNcap cell lysate, human cervical cancer tissue, human liver cancer tissue, LNcap. |
|---|---|
| Application Notes | WB:1:500-1:2,000 IHC:1:200-1:1,000 FC:1:50-1:100 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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