| 存储条件 |
|---|
| Product Name | HOXB4 [2F-2A] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Homeo box 2F antibody Homeo box B4 antibody Homeobox 2F antibody Homeobox B4 antibody Homeobox protein Hox B4 antibody Homeobox protein Hox-2.6 antibody Homeobox protein Hox-2F antibody Homeobox protein Hox-B4 antibody Homeobox protein HoxB4 antibody HOX 2 antibody Hox 2.6 antibody Hox 2F antibody HOX B4 antibody HOX2 antibody Hox2.6 antibody Hox2F antibody HOXB 4 antibody hoxb4 antibody HXB4_HUMAN antibody |
| Product description | The homeobox genes encode a family of transcription factors that regulate development and postnatal tissue homeostasis. Encoded by the HOXB4 gene, the nuclear phosphoprotein HoxB4 plays a key role in regulating the balance between hematopoietic stem cell renewal and differentiation. Hematopoietic expression of HoxB4 is regulated by the binding of USF-1 and USF-2, the binding of which may be favored by cytokines promoting stem cell self-renewal versus differentiation. HoxB4 is dependent on AP-1 expression to induce changes in cellular proliferation and differentiation, which increases the levels of cyclin D1, thereby linking HoxB4 with key elements of the cell cycle machinery. HoxB4 also participates in the down-regulation of c-Myc expression. It is expressed in developing hair follicles as well as in K-562 and HL-60 cells. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2a |
| Host Species | Mouse |
| Tested Applications | WBIHC |
| WB:1:500-1:2,000 IHC:1:200-1:1,000 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | Homeo box 2F antibody Homeo box B4 antibody Homeobox 2F antibody Homeobox B4 antibody Homeobox protein Hox B4 antibody Homeobox protein Hox-2.6 antibody Homeobox protein Hox-2F antibody Homeobox protein Hox-B4 antibody Homeobox protein HoxB4 antibody HOX 2 antibody Hox 2.6 antibody Hox 2F antibody HOX B4 antibody HOX2 antibody Hox2.6 antibody Hox2F antibody HOXB 4 antibody hoxb4 antibody HXB4_HUMAN antibody |
|---|---|
| Molecular Weight(MW) | 28 kDa |
| Cellular Localization | Nucleus. |
| SwissProt ID | P17483 |
|---|
Application
Fig1: Western blot analysis of HOXB4 on human HOXB4 recombinant protein using anti-HOXB4 antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of HOXB4 on HEK293 (1) and HOXB4-hIgGFc transfected HEK293 (2) cell lysate using anti-HOXB4 antibody at 1/1,000 dilution.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human rectum cancer tissue using anti-HOXB4 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-HOXB4 antibody. Counter stained with hematoxylin.| Positive Control | Human HOXB4 recombinant protein, HOXB4-hIgGFc transfected HEK293 cell lysate, human rectum cancer tissue, human colon cancer tissue. |
|---|---|
| Application Notes | WB:1:500-1:2,000 IHC:1:200-1:1,000 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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