| 存储条件 |
|---|
| Product Name | DNAJC15 [SY26-04] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | The DnaJ family is one of the largest of all the chaperone families and has evolved with diverse cellular localization and functions. The presence of a J domain defines a protein as a member of the DnaJ family. DnaJ heat shock induced proteins are from the bacterium Escherichia coli and are under the control of the htpR regulatory protein. The DnaJ proteins play a critical role in the HSP 70 chaperone machine by interacting with HSP 70 to stimulate ATP hydrolysis. DnaJ proteins are important mediators of proteolysis and are involved in the regulation of protein degradation, exocytosis and endocytosis. MCJ (methylation-controlled J protein), also known as HSD18, DNAJD1 or DNAJC15, is a 150 amino acid ubiquitously expressed single-pass membrane protein containing one J domain. Localizing to the golgi apparatus and only present in vertebrates, MCJ may be associated with increased chemotherapeutic resistance in ovarian cancer by inducing expression of the Mdr drug transporter and preventing intracellular drug accumulation. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WB,IHC |
| WB:1:1,000-1:5,000 IHC:1:50-1:200 | |
| Species Reactivity | Human,Mouse,Rat |
| Concentration | 1mg/ml |
| Purification | Unpurified |
| Alternative Names | Cell growth inhibiting gene 22 protein antibody Cell growth-inhibiting gene 22 protein antibody DJC15_HUMAN antibody DnaJ (Hsp40) homolog subfamily C member 15 antibody DNAJ domain containing antibody DnaJ homolog subfamily C member 15 antibody DNAJC15 antibody DNAJD1 antibody GIG22 antibody HSD18 antibody MCJ antibody Methylation controlled J protein antibody Methylation-controlled J protein antibody |
|---|---|
| Molecular Weight(MW) | 16 kDa |
| Cellular Localization | Mitochondrion inner membrane. |
Application
Fig1: Western blot analysis of DNAJC15 on human liver lysates using anti-DNAJC15 antibody at 1/1,000 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-DNAJC15 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-DNAJC15 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-DNAJC15 antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-DNAJC15 antibody. Counter stained with hematoxylin.
Application
Fig6: Immunohistochemical analysis of paraffin-embedded mouse heart tissue using anti-DNAJC15 antibody. Counter stained with hematoxylin.| Positive Control | Human liver cancer tissue, human liver tissue, human kidney tissue, mouse testis tissue, mouse heart tissue, mouse kidney tissue. |
|---|---|
| Application Notes | WB:1:1,000-1:5,000 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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