| 存储条件 |
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| Product Name | PDGF Receptor beta [SY10-08] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Platelet-derived growth factor (PDGF) is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PGDF-AA, PDGF-AB and PDGF-BB. These three isoforms bind with different affinities to two receptor types, PDGFR-α and –β, which are endowed with protein tyrosine kinase domains. PDGFR-α can bind to both A and B subunits of PDGF, while PDGFR-β can only bind the B subunit. Ligand binding promotes either homo- or heterodimerization of the PDGF receptors in a specific manner. PDGF-AA induces the dimerization of two α receptors, PDGF-AB induces dimerization of αα and αβ and PDGF-BB induces the formation of three types of dimers, αα, αβ and ββ. Translocation of the PDGFR-∫ gene with the Tel gene is linked to chronic myelomonocytic leukemia (CMML), a myelodysplastic syndrome, and demonstrates the oncogenic potential of the PDGF receptors. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WB,IHC,IP |
| WB:1:1,000-1:5,000 IHC:1:50-1:200 | |
| Species Reactivity | Human,Mouse,Rat |
| Concentration | 1mg/ml |
| Purification | Unpurified |
| Alternative Names | Beta platelet derived growth factor receptor antibody Beta-type platelet-derived growth factor receptor antibody CD 140B antibody CD140 antigen-like family member B antibody CD140b antibody CD140b antigen antibody IBGC4 antibody IMF1 antibody JTK12 antibody OTTHUMP00000160528 antibody PDGF R beta antibody PDGF-R-beta antibody PDGFR 1 antibody PDGFR antibody PDGFR beta antibody PDGFR1 antibody PDGFRB antibody PGFRB_HUMAN antibody Platelet derived growth factor receptor 1 antibody Platelet derived growth factor receptor beta antibody Platelet derived growth factor receptor beta polypeptide antibody |
|---|---|
| Molecular Weight(MW) | 170 kDa |
| Cellular Localization | Cell membrane, Cytoplasmic vesicle, Lysosome lumen. |
Application
Fig1: Western blot analysis of PDGF Receptor beta on NIH/3T3 cell lysates using anti-PDGF Receptor beta antibody at 1/1,000 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human lung tissue using anti-PDGF Receptor beta antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-PDGF Receptor beta antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse lung tissue using anti-PDGF Receptor beta antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-PDGF Receptor beta antibody. Counter stained with hematoxylin.| Positive Control | NIH/3T3, human lung tissue, human spleen tissue, mouse lung tissue, mouse brain tissue. |
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| Application Notes | WB:1:1,000-1:5,000 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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