| 存储条件 |
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| Product Name | CD130 [B11-B9-A8] |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3. Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism. Has a role in embryonic development. Does not bind IL6. Essential for survival of motor and sensory neurons and for differentiation of astrocytes. Required for expression of TRPA1 in nociceptive neurons. Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation. Required for normal trabecular bone mass and cortical bone composition. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2b |
| Host Species | Mouse |
| Tested Applications | WB,IHC,ICC |
| WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Purification | Unpurified |
| Alternative Names | CD130 antibody CD130 antigen antibody CDw130 antibody gp130 antibody GP130 RAPS antibody IL 6R beta antibody IL-6 receptor subunit beta antibody IL-6R subunit beta antibody IL-6R-beta antibody IL-6RB antibody IL6 ST antibody IL6RB_HUMAN antibody IL6ST antibody Interleukin 6 receptor subunit beta antibody Interleukin receptor beta chain antibody Interleukin-6 receptor subunit beta antibody Interleukin-6 signal transducer antibody Membrane glycoprotein 130 antibody Membrane glycoprotein gp130 antibody Oncostatin M receptor antibody Oncostatin M receptor alpha subunit antibody Oncostatin-M receptor subunit alpha antibody |
|---|---|
| Molecular Weight(MW) | 103 kDa |
| Cellular Localization | Cell membrane. |
| SwissProt ID | P40189 |
|---|
Application
Fig1: Western blot analysis of CD130 on CD130 recombinant protein using anti-CD130 antibody at 1/5,000 dilution.
Application
Fig2: Western blot analysis of CD130 on Raji cell (1) and mouse lung tissue (2) lysates using anti-CD130 antibody at 1/500 dilution.
Application
Fig3: ICC staining CD130 (green) in HUVEC cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig4: ICC staining CD130 (green) in LOVO cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-CD130 antibody. Counter stained with hematoxylin.
Application
Fig6: Immunohistochemical analysis of paraffin-embedded human prostate tissue using anti-CD130 antibody. Counter stained with hematoxylin.
Application
Fig7: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-CD130 antibody. Counter stained with hematoxylin.
Application
Fig8: Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-CD130 antibody. Counter stained with hematoxylin.| Positive Control | CD130 recombinant protein, Raji cell and mouse lung tissue lysates, HUVEC, LOVO, human prostate tissue, human liver tissue, human kidney tissue, human pancreas tissue. |
|---|---|
| Application Notes | WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide. |
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