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SirT1 (1F3) Mouse mAb

产品编号 : 8469S

英文名称 :

中文名称 : 抗体

品牌 : CST

包装规格	交货周期	质量标准	目录价	会员专享价	数量
100 µl	现货2-3天	原装正品	￥4550	登录后可见	- +

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基础信息产品详情相关文献

基础信息

存储条件	-20℃

产品详情

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Immunoprecipitation	1:100
Immunohistochemistry (Paraffin)	1:200 - 1:800
Immunofluorescence (Immunocytochemistry)	1:100

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

For a carrier free (BSA and azide free) version of this product see product #94642.

Specificity / Sensitivity

SirT1 (1F3) Mouse Monoclonal Antibody recognizes endogenous levels of total SirT1 protein.

Species Reactivity:

Human, Mouse, Rat, Monkey

Source / Purification

Monoclonal antibody is produced by immunizing animals with a recombinant protein representing the central region of human SirT1 protein.

Background

The Silent Information Regulator (SIR2) family of genes is a highly conserved group of genes that encode nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases, also known as class III histone deacetylases. The first discovered and best characterized of these genes is Saccharomyces cerevisiae SIR2, which is involved in silencing of mating type loci, telomere maintenance, DNA damage response, and cell aging (1). SirT1, the mammalian ortholog of Sir2, is a nuclear protein implicated in the regulation of many cellular processes, including apoptosis, cellular senescence, endocrine signaling, glucose homeostasis, aging, and longevity. Targets of SirT1 include acetylated p53 (2,3), p300 (4), Ku70 (5), forkhead (FoxO) transcription factors (5,6), PPARγ (7), and the PPARγ coactivator-1α (PGC-1α) protein (8). Deacetylation of p53 and FoxO transcription factors represses apoptosis and increases cell survival (2,3,5,6). Deacetylation of PPARγ and PGC-1α regulates the gluconeogenic/glycolytic pathways in the liver and fat mobilization in white adipocytes in response to fasting (7,8). SirT1 deacetylase activity is inhibited by nicotinamide and activated by resveratrol. In addition, SirT1 activity may be regulated by phosphorylation, as it is phosphorylated at Ser27 and Ser47 in vivo; however, the function of these phosphorylation sites has not yet been determined (9).

Alternate Names

75SirT1; hSIR2; hSIRT1; NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacylase sirtuin-1; Regulatory protein SIR2 homolog 1; SIR1; SIR2; sir2-like 1; SIR2-like protein 1; SIR2alpha; SIR2L1; SIRT1; SirtT1 75 kDa fragment; sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae); sirtuin 1; sirtuin type 1

Pathways

Explore pathways related to this product.

Select your Pathways AMPK SignalingProtein Acetylation

Database Links

UniProt ID: Q96EB6

Entrez-Gene Id: 23411

View in PhosphoSitePlus®

Product #8469
Citations: 282

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Showing 33 Images from 282 Citations

Reactive oxygen species regulate adipose-osteogenic lineage commitment of human mesenchymal stem cells by modulating gene expression of C/EBP homology protein and aldo-keto reductase family 1 member A1.

PDRN prevents SIRT1 degradation by attenuating autophagy during skin aging.

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Showing 282 Citations

Journal:

J Transl Med

Title:

Nicotinamide riboside attenuates radiation-induced intestinal injury by suppressing gasdermin E-medi...

Author:

Qian Zhou, et al.

Year:

2025

Applications:

Immunohistochemistry (IHC), Western Blotting (WB)

Reactivity:

Unspecified

Journal:

Adv Sci (Weinh)

Title:

Osteoblast-CD4+ CTL Crosstalk Mediated by SIRT1/DAAM2 Axis Prevents Age-Related Bone Loss.

Author:

Bin Yang, et al.

Year:

2025

Applications:

Western Blotting (WB)

Reactivity:

Unspecified

Journal:

Int J Mol Sci

Title:

Effect of Estrogen on Sirt1 Signaling in Human Macrophages.

Author:

Maria Luisa Barcena, et al.

Year:

2025

Applications:

Western Blotting (WB)

Reactivity:

Unspecified

Journal:

Aging Cell

Title:

SIRT1 Prevents Lens Epithelial Cell Senescence During Age-Related Cataract via Regulating p66Shc.

Author:

Huirui Liu, et al.

Year:

2025

Applications:

Unspecified

Reactivity:

Unspecified

Journal:

Front Cell Dev Biol

Title:

Epigenetic regulation of the respiratory chain by a mitochondrial distress-related redox signal.

Author:

Marius W Baeken, et al.

Year:

2025

Applications:

Unspecified

Reactivity:

Unspecified

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Page 1 of 57

SirT1 (1F3) Mouse mAb

Product Usage Information

Storage

Specificity / Sensitivity

Source / Purification

Background

Alternate Names

Pathways

Database Links

Product #8469Citations: 282

Product #8469
Citations: 282