首页 > 产品目录 > 免疫学 > 抗体 > IRE1alpha (14C10) Rabbit mAb

IRE1alpha (14C10) Rabbit mAb

产品编号 : 3294S

英文名称 :

中文名称 : 抗体

品牌 : CST

包装规格	交货周期	质量标准	目录价	会员专享价	数量
100 µl	现货2-3天	原装正品	￥4550	登录后可见	- +

SDS搜索产品说明书 COA搜索

发送询价加入购物车

基础信息产品详情相关文献

基础信息

存储条件	-20℃

产品详情

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Simple Western™	1:10 - 1:50
Immunoprecipitation	1:50

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

IRE1 alpha (14C10) Rabbit Monoclonal Antibody detects endogenous levels of total IRE1α protein.

Species Reactivity:

Human, Mouse, Rat

Source / Purification

IRE1α (14C10) Rabbit mAb is produced by immunizing rabbits with a synthetic peptide corresponding to residues surrounding His963 of human IRE1α.

Background

The secretory, intra-organellar and transmembrane proteins translocate into the endoplasmic reticulum (ER) after their synthesis. Inside the ER, they are post-translationally modified and properly folded. Disruptions of ER homeostasis leads to the accumulation of unfolded proteins (1). The ER has developed an adaptive mechanism called unfolded protein response (UPR) to counteract compromised protein folding (1). One of the players in UPR, IRE1, was first identified in Saccharomyces cerevisiae as a transmembrane serine/threonine kinase (2-4). This kinase was proposed to be a proximal sensor for UPR that transmits the unfolded protein signal across the ER membrane (3,4). A human homolog of this kinase, IRE1α, was later identified and shown to be ubiquitously expressed in human tissues (5). Upon activation of UPR, IRE1α splices X-box binding protein (XBP1) mRNA by an unconventional mechanism using its endoribonuclease activity (6). This converts XBP1 into a potent transcriptional activator that induces many UPR responsive genes (6). Recently, IRE1α was shown to mediate the rapid degradation of certain mRNAs based on the ER-localization and primary sequences of their encoded proteins, suggesting a novel mechanism in UPR (7).

Alternate Names

endoplasmic reticulum to nucleus signaling 1; endoplasmic reticulum to nucleus signalling 1; Endoplasmic reticulum-to-nucleus signaling 1; Endoribonuclease; ER to nucleus signalling 1; ERN1; FLJ30999; hIRE1p; inositol-requiring 1; inositol-requiring enzyme 1; Inositol-requiring protein 1; IRE1; Ire1-alpha; IRE1a; IRE1P; MGC163277; MGC163279; protein kinase/endoribonuclease; Serine/threonine-protein kinase; Serine/threonine-protein kinase/endoribonuclease IRE1

相关文献

抱歉，暂无相关文献

浏览记录