| 存储条件 |
|---|
| Product Name | Mouse monoclonal antibody to caspase-11 p20 |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Amino acids 141-195 of caspase-11 of mouse origin. |
| Clonality | monoclonal |
|---|---|
| Isotype | IgG1, k |
| Host Species | Mouse |
| Tested Applications | WB |
| WB:1:100-1:1000 | |
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | Casp4 |
|---|---|
| Gene Synonyms | Caspl ich-3 CASP-4 Casp11 CASP-11 |
| Gene Full Name | caspase 4, apoptosis-related cysteine peptidase |
| Gene Summary | This gene encodes a member of the cysteine proteases that plays important roles in apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4, apoptosis-related cysteine peptidase", this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9. [provided by RefSeq, Apr 2015] |
| Molecular Weight(MW) | Molecular Weight of caspase-11 precursor: 48 kDa. Molecular Weight of caspase-11 p20 subunit: 20 kDa. |
| Cellular Localization | Cytoplasm,Membrane,Secreted. |
WB
Western blot analysis of procaspase-11 expression in LPS/IFNγ treated RAW264.7(A) and C6(B) whole cell lysates.| Application Notes | WB:1:100-1:1000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4° C, **DO NOT FREEZE**. Stable for one year from the date of shipment. Non-hazardous. No MSDS required. |
| Storage Buffer | Each vial contains 200 µg IgG1 kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin. |
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