This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Alternative Names
2'-5'-oligoadenylate synthetase 2
Molecular Weight(MW)
82kDa
Cellular Localization
Cytoplasm.
Application
WB
Gel:8%SDS-PAGE, Lysate: 40μg. Lane: A172 cel lysate. Primary antibody: OAS2 Antibody at dilution 1/1000. Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution. Exposure time: 30 seconds.
