| 存储条件 |
|---|
| Product Name | Mouse Monoclonal Antibody to IRF3 |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Purified recombinant fragment of human IRF3 (AA: 1-150) expressed in HEK293-6e cells supernatant. |
| Clonality | monoclonal |
|---|---|
| Isotype | IgG2b |
| Host Species | Mouse |
| Tested Applications | FCICC/IFIHC |
| IHC:1:200-1:1000 ICC/IF:1:200-1:1000 FC:1:200-1:400 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | IRF3 |
|---|---|
| Gene Synonyms | IIAE7 |
| Gene Full Name | interferon regulatory factor 3 |
| Gene Summary | This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The protein plays an important role in the innate immune response against DNA and RNA viruses. Mutations in this gene are associated with Encephalopathy, acute, infection-induced, herpes-specific, 7. [provided by RefSeq, Sep 2020] |
| Alternative Names | IIAE7 |
| Molecular Weight(MW) | 47kDa |
| Cellular Localization | Cytoplasm,Nucleus,Mitochondrion. |
IHC
Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using IRF3 mouse mAb with DAB staining.
IHC
Immunohistochemical analysis of paraffin-embedded human lung cancer tissues using IRF3 mouse mAb with DAB staining.
IHC
Immunohistochemical analysis of paraffin-embedded mouse liver tissues using IRF3 mouse mAb with DAB staining.
ICC/IF
Immunofluorescence analysis of Hela cells using IRF3 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
FC
Flow cytometric analysis of Hela cells using IRF3 mouse mAb (green) and negative control (red).| Application Notes | IHC:1:200-1:1000 ICC/IF:1:200-1:1000 FC:1:200-1:400 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide. |
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