| 存储条件 |
|---|
| Product Name | SLC7A11/xCT Polyclonal antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Recombinant human SLC7A11 protein |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHCIPWB |
| WB:1:500-1:2000 IHC:1:500-1:2000 IP:0.5-4.0 ug for 1.0-3.0 mg of total protein lysate | |
| Species Reactivity | Human |
| Concentration | 0.5mg/ml |
| Purification | Affinity purified |
| Gene Symbol | SLC7A11 |
|---|---|
| Gene Synonyms | xCT CCBR1 |
| Gene Full Name | solute carrier family 7 member 11 |
| Gene Summary | This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011] |
| Alternative Names | SLC7A11 xCT Amino acid transport system xc Amino acid transport system xc- CCBR1 |
| Molecular Weight(MW) | 55 kDa, 35-40 kDa |
| Cellular Localization | Cell membrane |
WB
Various lysates were subjected to SDS PAGE followed by western blot with SLC7A11/xCT antibody at dilution of 1:1000 incubated at room temperature for 1.5 hours.
IHC
Immunohistochemical analysis of paraffin embedded human renal cell carcinoma tissue slide using SLC7A11/xCT antibody at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).
IP
IP result of anti-SLC7A11/xCT (IP:4ug; Detection:1:800) with A549 cells lysate 1mg.| Application Notes | WB:1:500-1:2000 IHC:1:500-1:2000 IP:0.5-4.0 ug for 1.0-3.0 mg of total protein lysate |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at -20°C. Stable for one year after shipment. |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
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