| 存储条件 |
|---|
| Product Name | WNT4 [4G1] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MGC123964 antibody Protein Wnt-4 antibody RP23-246F18.1 antibody SERKAL antibody Wingless type MMTV integration site family member 4 precursor antibody WNT 4 antibody WNT 4 protein precursor antibody WNT4 antibody WNT4_HUMAN antibody |
| Product description | Products of the highly conserved Wnt gene family, including Wnt-1 through Wnt-10, play key roles in regulating cellular growth and differentiation. Wnt-1 is a cysteine-rich, secreted glycoprotein that associates with cell membranes and likely functions as a key regulator of cellular adhesion. Wnt-1, which is essential for normal development of the embryonic nervous system, contributes to hyperplasia and tumorigenic progression when improperly expressed in mammary tissue. Wnt-3 is also involved in tumorigenesis, and Wnt-2 and Wnt-4 may be associated with abnormal proliferation in human breast tissue.Wnt-1, Wnt-3 and Wnt-10b have been implicated along with FGF-3 in the development of mouse mammary tumor virus-induced mouse mammary carcinomas.Wnt family members have been shown to interact with Sonic hedgehog (Shh) in vivo to induce myogenesis in somitic tissue. |
| Immunogen | peptide |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIPIFIHC |
| WB:1:1,000 IP:1-2 μg per 100-500 μg of total protein IF:1:50-500 IHC:1:50-500 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 2mg/ml |
| Alternative Names | MGC123964 antibody Protein Wnt-4 antibody RP23-246F18.1 antibody SERKAL antibody Wingless type MMTV integration site family member 4 precursor antibody WNT 4 antibody WNT 4 protein precursor antibody WNT4 antibody WNT4_HUMAN antibody |
|---|---|
| Molecular Weight(MW) | 40 kDa |
| Cellular Localization | Secreted |
| SwissProt ID | P56705 |
|---|
Application
Fig1: Western blot analysis of Wnt-4 expression in L929 (A) CSMLO (B), ESD3 (C) and ESD5 (D) whole cell lysates.
Application
Fig2： Immunoperoxidase staining of formalin fixed, paraffin-embedded human spleen tissue showing cytoplasmic staining of cells in white pulp.| Positive Control | L929, CSMLO, ESD3, ESD5, human spleen tissue. |
|---|---|
| Application Notes | WB:1:1,000 IP:1-2 μg per 100-500 μg of total protein IF:1:50-500 IHC:1:50-500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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