| 存储条件 |
|---|
| Product Name | TAB1 [1G2] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | 2310012M03Rik antibody 3'-Tab1 antibody MAP3K7IP 1 antibody MAP3K7IP1 antibody MGC57664 antibody Mitogen activated protein kinase kinase kinase 7 interacting protein 1 antibody Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 antibody TAB 1 antibody TAB1 antibody TAB1_HUMAN antibody TAK1 binding protein 1 antibody TAK1-binding protein 1 antibody TGF beta activated kinase 1 binding protein 1 antibody TGF-beta activated kinase 1/MAP3K7 binding protein 1 antibody TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 antibody TGF-beta-activated kinase 1-binding protein 1 antibody Transforming growth factor beta activated kinase binding protein 1 antibody |
| Product description | The TAK1 binding proteins, TAB1, TAB2 and TAB3, interact with the MAPKKK TAK1 in response to various stimuli. TAB1 activates TAK1 in TGFβ mediated signaling. TAB1 also plays a central role in a p38α activation pathway that is independent of MAPKK. In response to pro-inflammatory signals, TAB2 complexes with TRAF6 and TAK1, leading to translocation of the complex from the membrane to the cytosol and the subsequent activation of TAK1. When overexpressed, TAB3 activates both NFκB and AP-1 transcription factors. In response to TNFα or IL-1, TAK1 complexes with TAB1 and TAB2 or with TAB1 and TAB3 to yield two distinct complexes. |
| Immunogen | peptide |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIPIF |
| WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) IF:1:50-1:500 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | 2310012M03Rik antibody 3'-Tab1 antibody MAP3K7IP 1 antibody MAP3K7IP1 antibody MGC57664 antibody Mitogen activated protein kinase kinase kinase 7 interacting protein 1 antibody Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 antibody TAB 1 antibody TAB1 antibody TAB1_HUMAN antibody TAK1 binding protein 1 antibody TAK1-binding protein 1 antibody TGF beta activated kinase 1 binding protein 1 antibody TGF-beta activated kinase 1/MAP3K7 binding protein 1 antibody TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 antibody TGF-beta-activated kinase 1-binding protein 1 antibody Transforming growth factor beta activated kinase binding protein 1 antibody |
|---|---|
| Molecular Weight(MW) | 56kDa |
| SwissProt ID | Q15750 |
|---|
Application
Fig1: Western blot analysis of TAB1 expression in non-transfected (A) and human TAB1 transfected (B) 293T whole cell lysates.| Positive Control | 293T |
|---|---|
| Application Notes | WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) IF:1:50-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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