| 存储条件 |
|---|
| Product Name | RIM 2 [3G2] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | KIAA0751 antibody Non small cell lung cancer RimL3a protein antibody Non small cell lung cancer RimL3c protein antibody OBOE antibody Protein regulating synaptic membrane exocytosis 2 antibody Rab-3-interacting molecule 2 antibody Rab-3-interacting protein 3 antibody Rab3 interacting molecule 2 antibody RAB3IP3 antibody Regulating synaptic membrane exocytosis 2 antibody Regulating synaptic membrane exocytosis protein 2 antibody RIM 2 antibody Rims2 (gene name) antibody Rims2 antibody RIMS2_HUMAN antibody |
| Product description | Rab3, a neural/neuroendocrine-specific member of the Rab family, is involved in Ca2+-regulated exocytosis. Rab3 functions in an inhibitory capacity by controlling the recruitment of secretory vesicles into a releasable pool at the plasma membrane. Rim (rab3 interacting molecule), a putative effector protein for Rab3s, is composed of an N-terminal zinc-finger motif and C-terminal PDZ and C2 domains. Rim exists as two variants, Rim1 and Rim2, produced by alternative splicing. The 3’-end of the Rim2 gene produces an independent mRNA that encodes a smaller protein referred to as Nim2, which like Rim, also regulates exocytosis. Rim serves as a Rab3-dependent regulator of synaptic-vesicle fusion by forming a GTP-dependent complex between synaptic plasma membranes and docked synaptic vesicles. Both Rim1 and Rim2 can bind to cAMP-GEFII, which is a direct target of cAMP in regulated exocytosis and is responsible for cAMP-dependent, PKA-dependent exocytosis. Rim also localizes on the plasma membrane of INS-1E cells and pancreatic beta-cells. Rab3 binding domain of Rim enhances glucose-stimulated secretion in intact cells and Ca2+-stimulated exocytosis in permeabilized cells, suggesting that Rim may also play a regulatory role in insulin secretion. |
| Immunogen | peptide |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIP |
| WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) IF:1:50-500 IHC:1:50-500 | |
| Species Reactivity | HumanRat |
| Concentration | 2mg/ml |
| Alternative Names | KIAA0751 antibody Non small cell lung cancer RimL3a protein antibody Non small cell lung cancer RimL3c protein antibody OBOE antibody Protein regulating synaptic membrane exocytosis 2 antibody Rab-3-interacting molecule 2 antibody Rab-3-interacting protein 3 antibody Rab3 interacting molecule 2 antibody RAB3IP3 antibody Regulating synaptic membrane exocytosis 2 antibody Regulating synaptic membrane exocytosis protein 2 antibody RIM 2 antibody Rims2 (gene name) antibody Rims2 antibody RIMS2_HUMAN antibody |
|---|---|
| Molecular Weight(MW) | 160kDa |
| Cellular Localization | Cell membrane, Cell junction |
| SwissProt ID | Q9UQ26 |
|---|
Application
Fig1: Western blot analysis of Rim2 expression in PC-12 whole cell lysate.| Positive Control | PC-12 |
|---|---|
| Application Notes | WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) IF:1:50-500 IHC:1:50-500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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