| 存储条件 |
|---|
| Product Name | OGG1 [1G4] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | 8 hydroxyguanine DNA glycosylase antibody 8 oxoguanine DNA glycosylase 1 antibody 8 oxoguanine DNA glycosylase antibody AP lyase antibody DNA (apurinic or apyrimidinic site) lyase antibody DNA apurinic or apyrimidinic site lyase antibody DNA lyase antibody DNA-(apurinic or apyrimidinic site) lyase antibody HMMH antibody HOGG 1 antibody HOGG1 antibody MMH antibody MUTM antibody N glycosylase antibody Ogg 1 antibody Ogg1 antibody OGG1_HUMAN antibody OGH 1 antibody OGH1 antibody Ig gamma-2 chain C region antibody IGHG2 antibody immunoglobulin Gm2 antibody immunoglobulin heavy constant gamma 2 (G2m marker) antibody immunoglobulin heavy constant, gamma 2 antibody |
| Product description | 8-oxoguanine (8-oxoG), an oxidized form of guanine, is produced by reactive oxygen species in both DNA and nucleotide pools during normal aging. Accumulation of 8-oxoG increases the occurrence of A:T to C:G or G:C to T:A transversion mutations, because 8-oxoG forms a stable basepair with adenine as well as with cytosine. OGG1 (for 8-oxoG DNA glycosylase), also designated MMH, is a DNA repair enzyme that corrects these mutations. Inactivation of the OGG1 gene leads to a mutator phenotype, characterized by the increase in G:C to T:A transversions. The OGG1 gene encodes eight isoforms (OGG1A-C, OGG2A-E) which result from alternative splicing of a single messenger RNA. The OGG1A splice variant is the most prevalent form and localizes to the nucleus, whereas the OGG2A splice variant is targeted to the mitochondria. |
| Immunogen | peptide |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIPIF |
| WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) IF:1:50-1:500 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 2mg/ml |
| Alternative Names | 8 hydroxyguanine DNA glycosylase antibody 8 oxoguanine DNA glycosylase 1 antibody 8 oxoguanine DNA glycosylase antibody AP lyase antibody DNA (apurinic or apyrimidinic site) lyase antibody DNA apurinic or apyrimidinic site lyase antibody DNA lyase antibody DNA-(apurinic or apyrimidinic site) lyase antibody HMMH antibody HOGG 1 antibody HOGG1 antibody MMH antibody MUTM antibody N glycosylase antibody Ogg 1 antibody Ogg1 antibody OGG1_HUMAN antibody OGH 1 antibody OGH1 antibody Ig gamma-2 chain C region antibody IGHG2 antibody immunoglobulin Gm2 antibody immunoglobulin heavy constant gamma 2 (G2m marker) antibody immunoglobulin heavy constant gamma 2 antibody |
|---|---|
| Molecular Weight(MW) | OGG-1: 38 kDa, OGG-2: 36 kDa |
| Cellular Localization | Nucleus, Nucleus speckle, ucleus matrix Mitochondrion |
| SwissProt ID | O15527 |
|---|
Application
Fig1: Western blot analysis of OGG1/2 expression in HeLa whole cell lysate.| Positive Control | Hela. |
|---|---|
| Application Notes | WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) IF:1:50-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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