| 存储条件 |
|---|
| Product Name | MKP-3 [3G1] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Dual specificity phosphatase 6 antibody Dual specificity phosphatase 6 isoform a antibody Dual specificity protein phosphatase 6 antibody Dual specificity protein phosphatase PYST1 antibody DUS6_HUMAN antibody DUSP 6 antibody DUSP 6a antibody Dusp6 antibody DUSP6a antibody HH19 antibody MAP kinase phosphatase 3 antibody Mitogen activated protein kinase phosphatase 3 antibody Mitogen-activated protein kinase phosphatase 3 antibody MKP 3 antibody MKP-3 antibody MKP3 antibody PYST 1 antibody PYST1 antibody Serine/threonine specific protein phosphatase antibody hide |
| Product description | Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. The members of the dual-specificity phosphatase protein family include MKP-1/CL100 (3CH134), VHR, PAC1, MKP-2, hVH-3 (B23), hVH-5, MKP-3, MKP-X, and MKP-4. Human MKP-3 maps to chromosome 12q21.33 and encodes a 381 amino acid protein that specifically inactivates members of the ERK family and is expressed in a variety of tissues with the highest levels in heart and pancreas. |
| Immunogen | peptide |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIPIFIHC-P |
| WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) IF:1:50-1:500 IHC:1:50-1:500 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 2mg/ml |
| Alternative Names | Dual specificity phosphatase 6 antibody Dual specificity phosphatase 6 isoform a antibody Dual specificity protein phosphatase 6 antibody Dual specificity protein phosphatase PYST1 antibody DUS6_HUMAN antibody DUSP 6 antibody DUSP 6a antibody Dusp6 antibody DUSP6a antibody HH19 antibody MAP kinase phosphatase 3 antibody Mitogen activated protein kinase phosphatase 3 antibody Mitogen-activated protein kinase phosphatase 3 antibody MKP 3 antibody MKP-3 antibody MKP3 antibody PYST 1 antibody PYST1 antibody Serine/threonine specific protein phosphatase antibody hide |
|---|---|
| Molecular Weight(MW) | 42 kDa |
| Cellular Localization | Cytoplasm |
| SwissProt ID | Q16828 |
|---|
Application
Fig1: Western blot analysis of MKP-3 expression in non-transfected (A) and human MKP-3 transfected (B) 293T whole cell lysates.
Application
Fig2： Immunoperoxidase staining of formalin fixed, paraffin-embedded human bronchus tissue showing cytoplasmic staining of respiratory epithelial cells.| Positive Control | 293T, human bronchus tissue. |
|---|---|
| Application Notes | WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein(1 ml of cell lysate) IF:1:50-1:500 IHC:1:50-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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