| 存储条件 |
|---|
| Product Name | ALAS2 [12-D] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | 5 @aminolevulinate synthase erythroid specific antibody 5 aminolevulinate synthase 2 antibody 5 aminolevulinate synthase 5 aminolevulinate synthase 2 antibody 5 aminolevulinate synthase erythroid specific mitochondrial antibody 5 aminolevulinic acid synthase 2 antibody 5 aminolevulinic acid synthase antibody 5-aminolevulinate synthase antibody 5-aminolevulinic acid synthase 2 antibody Alas 2 antibody ALAS antibody ALAS E antibody ALAS, erythroid antibody ALAS-E antibody Alas2 antibody ALASE antibody Aminolevulinate delta synthase 2 antibody Aminolevulinic acid synthase 2, erythroid antibody ANH1 antibody ASB antibody Delta ALA synthase 2 antibody Delta ALA synthetase antibody Delta aminolevulinate synthase 2 antibody Delta aminolevulinate synthase antibody Delta-ALA synthase 2 antibody Delta-aminolevulinate synthase 2 antibody Erythroid specific ALAS antibody erythroid-specific antibody FLJ93603 antibody HEM0_HUMAN antibody mitochondrial antibody OTTHUMP00000023388 antibody OTTHUMP00000023389 antibody OTTMUSP00000020679 antibody RP23-338A17.1 antibody SIDBA1 antibody XLDPP antibody XLEPP antibody XLSA antibody |
| Product description | 5-aminolevulinate synthase 1 (ALAS-H) and 2 (ALAS-E) are two isoforms of ALAS, an enzyme catalyzing the first step of the heme biosynthetic pathway in mammals. The erythroid-specific isoenzyme, ALAS-E, regulates the first step of hematopoietic cell differentation and iron metabolism in the liver. ALAS-H is a housekeeping protein which mediates synthesis of early heme in the mitochondria of most cells. Succinyl CoA associates with ALAS-E in protein conformation change and translocation of ALAS-E into the mitochondria and does not interact with ALAS-H. The ALAS-E 5'-flanking region contains binding sites for nuclear activators such as GATA-1, NF-E2 and EKLF. Since the ALAS gene maps to the X chromosome, mutation of the gene leads to the pyridoxine-refractory X-linked sideroblastic anemia. |
| Immunogen | peptide |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIPIFIHC-P |
| WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein (1 ml of cell lysate) IF:1:50-500 IHC:1:50-500 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 2mg/ml |
| Alternative Names | 5 @aminolevulinate synthase erythroid specific antibody 5 aminolevulinate synthase 2 antibody 5 aminolevulinate synthase 5 aminolevulinate synthase 2 antibody 5 aminolevulinate synthase erythroid specific mitochondrial antibody 5 aminolevulinic acid synthase 2 antibody 5 aminolevulinic acid synthase antibody 5-aminolevulinate synthase antibody 5-aminolevulinic acid synthase 2 antibody Alas 2 antibody ALAS antibody ALAS E antibody ALAS erythroid antibody ALAS-E antibody Alas2 antibody ALASE antibody Aminolevulinate delta synthase 2 antibody Aminolevulinic acid synthase 2 erythroid antibody ANH1 antibody ASB antibody Delta ALA synthase 2 antibody Delta ALA synthetase antibody Delta aminolevulinate synthase 2 antibody Delta aminolevulinate synthase antibody Delta-ALA synthase 2 antibody Delta-aminolevulinate synthase 2 antibody Erythroid specific ALAS antibody erythroid-specific antibody FLJ93603 antibody HEM0_HUMAN antibody mitochondrial antibody OTTHUMP00000023388 antibody OTTHUMP00000023389 antibody OTTMUSP00000020679 antibody RP23-338A17.1 antibody SIDBA1 antibody XLDPP antibody XLEPP antibody XLSA antibody |
|---|---|
| Molecular Weight(MW) | 60 kDa |
| Cellular Localization | Cytoplasm |
| SwissProt ID | P22557 |
|---|
Application
Fig2： Immunoperoxidase staining of formalin fixed, paraffin-embedded human cervix tissue showing cytoplasmic staining of squamous epithelial cells.Application
Fig2： Immunoperoxidase staining of formalin fixed, paraffin-embedded human cervix tissue showing cytoplasmic staining of squamous epithelial cells.| Positive Control | 293T, SK-BR-3, PC-3M, human cervix tissue. |
|---|---|
| Application Notes | WB:1:100-1:1,000 IP:1-2 μg per 100-500 μg of total protein (1 ml of cell lysate) IF:1:50-500 IHC:1:50-500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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