| 存储条件 |
|---|
| Product Name | Tim3 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CD366 antibody FLJ14428 antibody HAVcr-2 antibody Havcr2 antibody HAVR2_HUMAN antibody Hepatitis A virus cellular receptor 2 antibody Kidney injury molecule 3 antibody KIM 3 antibody KIM3 antibody T cell immunoglobulin and mucin domain containing 3 antibody T cell immunoglobulin mucin 3 antibody T-cell immunoglobulin and mucin domain-containing protein 3 antibody T-cell immunoglobulin mucin family member 3 antibody T-cell immunoglobulin mucin receptor 3 antibody T-cell membrane protein 3 antibody Tim 3 antibody TIM-3 antibody TIM3 antibody TIMD-3 antibody TIMD3 antibody |
| Product description | Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse. |
| Immunogen | Peptide |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBICCIHC |
| WB:1:500~1:2000 ICC:1:200~1:500 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. | |
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Alternative Names | CD366 antibody FLJ14428 antibody HAVcr-2 antibody Havcr2 antibody HAVR2_HUMAN antibody Hepatitis A virus cellular receptor 2 antibody Kidney injury molecule 3 antibody KIM 3 antibody KIM3 antibody T cell immunoglobulin and mucin domain containing 3 antibody T cell immunoglobulin mucin 3 antibody T-cell immunoglobulin and mucin domain-containing protein 3 antibody T-cell immunoglobulin mucin family member 3 antibody T-cell immunoglobulin mucin receptor 3 antibody T-cell membrane protein 3 antibody Tim 3 antibody TIM-3 antibody TIM3 antibody TIMD-3 antibody TIMD3 antibody |
|---|---|
| Molecular Weight(MW) | 40 kDa/70 kDa(additional band) |
| Cellular Localization | Cell junction, Membrane. |
Application
Fig1: Western blot analysis of Tim3 on different lysates using anti-Tim3 antibody at 1/500 dilution. Positive control：Lane1: HelaLane2: Mouse spleenLane3: PC-3M
Application
Fig2: ICC staining Tim3 in Hela cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-Tim3 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti- Tim3 antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded mouse spleen tissue using anti- Tim3 antibody. Counter stained with hematoxylin.| Positive Control | Hela, mouse spleen tissue, PC-3M cell lysate, human spleen tissue, human breast cancer tissue. |
|---|---|
| Application Notes | WB:1:500~1:2000 ICC:1:200~1:500 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide. |
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