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| Product Name | ACO1 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | ACO 1 antibody ACO1 antibody ACOC_HUMAN antibody Aconitase 1 soluble antibody Aconitase antibody Aconitase1 antibody Aconitate hydratase antibody ACONS antibody Citrate hydro lyase antibody Citrate hydro-lyase antibody Cytoplasmic aconitate hydratase antibody Ferritin repressor protein antibody IRE BP 1 antibody IRE-BP 1 antibody IREB 1 antibody IREB1 antibody IREBP antibody IREBP1 antibody Iron regulatory protein 1 antibody Iron responsive element binding protein 1 antibody Iron-responsive element-binding protein 1 antibody IRP 1 antibody IRP1 antibody OTTHUMP00000045233 antibody |
| Product description | Iron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins; iron regulatory protein-1 and -2 (IRP-1 and -2), also known as iron responsive element-binding protein-1 and -2 (IRE-BP-1 and -2) or aconitase 1 and 2. IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells. They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs). IRPs respond to stress mediators, iron concentration and signaling factors, including nitrogen monoxide, cytokines and hydrogen peroxide. |
| Immunogen | Recombinant protein. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIHCICC |
| WB:1:500~1:2000 IHC:1:50~1:200 ICC:1:200~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher. | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | ACO 1 antibody ACO1 antibody ACOC_HUMAN antibody Aconitase 1 soluble antibody Aconitase antibody Aconitase1 antibody Aconitate hydratase antibody ACONS antibody Citrate hydro lyase antibody Citrate hydro-lyase antibody Cytoplasmic aconitate hydratase antibody Ferritin repressor protein antibody IRE BP 1 antibody IRE-BP 1 antibody IREB 1 antibody IREB1 antibody IREBP antibody IREBP1 antibody Iron regulatory protein 1 antibody Iron responsive element binding protein 1 antibody Iron-responsive element-binding protein 1 antibody IRP 1 antibody IRP1 antibody OTTHUMP00000045233 antibody |
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| Molecular Weight(MW) | 98 kDa |
| Cellular Localization | Cytoplasm. |
Application
Fig1: Western blot analysis of ACO1 on mouse liver tissue lysate using anti-ACO1 antibody at 1/1,000 dilution.
Application
Fig2: ICC staining ACO1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig3: ICC staining ACO1 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human thyroid tissue using anti-ACO1 antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-ACO1 antibody. Counter stained with hematoxylin.
Application
Fig6: Immunohistochemical analysis of paraffin-embedded mouse thyroid tissue using anti-ACO1 antibody. Counter stained with hematoxylin.
Application
Fig7: Immunohistochemical analysis of paraffin-embedded mouse ovary tissue using anti-ACO1 antibody. Counter stained with hematoxylin.
Application
Fig8: Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-ACO1 antibody. Counter stained with hematoxylin.| Positive Control | Mouse liver tissue lysate, Hela, HepG2, human thyroid tissue, human kidney tissue, mouse thyroid tissue, mouse kidney tissue, mouse ovary tissue. |
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| Application Notes | WB:1:500~1:2000 IHC:1:50~1:200 ICC:1:200~1:500 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 0.5%BSA, 50%Glycerol. Preservative: 0.05% Sodium Azide. |
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