| 存储条件 |
|---|
| Product Name | Nrf2 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | erythroid derived 2 antibody HEBP1 antibody like 2 antibody NF E2 related factor 2 antibody NF-E2-related factor 2 antibody NF2L2_HUMAN antibody NFE2 related factor 2 antibody NFE2-related factor 2 antibody Nfe2l2 antibody Nrf 2 antibody NRF2 antibody Nuclear factor (erythroid derived 2) like 2 antibody Nuclear factor antibody nuclear factor erythroid 2 like 2 antibody Nuclear factor erythroid 2 related factor 2 antibody Nuclear factor erythroid 2-related factor 2 antibody Nuclear factor erythroid derived 2 like 2 antibody |
| Product description | The Nrf2 antioxidant response pathway is "the primary cellular defense against the cytotoxic effects of oxidative stress." Among other effects, NFE2L2 increases the expression of several antioxidant enzymes. Several drugs that stimulate the NFE2L2 pathway are being studied for treatment of diseases that are caused by oxidative stress, and dimethyl fumarate significantly reduced the progression of disability in multiple sclerosis. Under normal or unstressed conditions, Nrf2 is kept in the cytoplasm by a cluster of proteins that degrade it quickly. Under oxidative stress, Nrf2 is not degraded, but instead travels to the nucleus where it binds to a DNA promoter and initiates transcription of antioxidative genes and their proteins. |
| Immunogen | This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to Nrf2 aa 530-600. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBICC |
| WB:1:1000-1:2000 ICC:1:100 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | erythroid derived 2 antibody HEBP1 antibody like 2 antibody NF E2 related factor 2 antibody NF-E2-related factor 2 antibody NF2L2_HUMAN antibody NFE2 related factor 2 antibody NFE2-related factor 2 antibody Nfe2l2 antibody Nrf 2 antibody NRF2 antibody Nuclear factor (erythroid derived 2) like 2 antibody Nuclear factor antibody nuclear factor erythroid 2 like 2 antibody Nuclear factor erythroid 2 related factor 2 antibody Nuclear factor erythroid 2-related factor 2 antibody Nuclear factor erythroid derived 2 like 2 antibody |
|---|---|
| Molecular Weight(MW) | 68 kDa |
| Cellular Localization | Cytoplasm, Nucleus |
| SwissProt ID | Q16236 |
|---|
Application
Fig1: Western blot analysis on different lysates using anti-Nrf2 rabbit polyclonal antibodies.
Application
Fig2: ICC staining Nrf2 in Hela cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.| Positive Control | Raji, mouse liver, HepG2, Hela |
|---|---|
| Application Notes | WB:1:1000-1:2000 ICC:1:100 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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