| 存储条件 |
|---|
| Product Name | GSK3 alpha |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DKFZp686D0638 antibody Glycogen synthase kinase 3 alpha antibody Glycogen synthase kinase-3 alpha antibody GSK 3 alpha antibody GSK 3A antibody GSK-3 alpha antibody Gsk3a antibody GSK3A_HUMAN antibody GSK3alpha antibody Serine/threonine protein kinase GSK3A antibody |
| Product description | Glycogen synthase kinase-3 alpha is an enzyme that in humans is encoded by the GSK3A gene. It acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. GSK3 alpha requires primed phosphorylation of the majority of its substrates. It contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. GSK3 alpha regulates glycogen metabolism in liver, but not in muscle. It may also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, GSK3 alpha regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. |
| Immunogen | peptide |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBICCIHCFC |
| WB:1:1000 ICC:1:100 | |
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | DKFZp686D0638 antibody Glycogen synthase kinase 3 alpha antibody Glycogen synthase kinase-3 alpha antibody GSK 3 alpha antibody GSK 3A antibody GSK-3 alpha antibody Gsk3a antibody GSK3A_HUMAN antibody GSK3alpha antibody Serine/threonine protein kinase GSK3A antibody |
|---|---|
| Molecular Weight(MW) | 51 kDa |
| Cellular Localization | Cytoplasm |
| SwissProt ID | P49840 |
|---|
Application
Fig1: Western blot analysis on different cell lysates using anti-GSK3 alpha rabbit polyclonal antibodies.
Application
Fig2: ICC staining GSK3 alpha in Hela cells (green). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.| Positive Control | Hela, HepG2, PC-3M, Jurkat, human brain |
|---|---|
| Application Notes | WB:1:1000 ICC:1:100 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 0.5%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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