| 存储条件 |
|---|
| Product Name | Dystrophin [JF1-022] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | BMD antibody CMD3B antibody DMD antibody DMD_HUMAN antibody Duchenne muscular dystrophy protein antibody Dystrophin antibody Muscular dystrophy Duchenne and Becker types antibody |
| Product description | Dystrophin-glycoprotein complex (DGC) connects the F-Actin cytoskeleton on the inner surface of muscle fibers to the surrounding extracellular matrix, through the cell membrane interface. A deficiency in this protein contributes to Duchenne (DMD) and Becker (BMD) muscular dystrophies. The human dystrophin gene measures 2.4 megabases, has more than 80 exons, produces a 14 kb mRNA and contains at least eight independent tissue-specific promoters and two poly A sites. The dystrophin mRNA can undergo differential splicing and produce a range of transcripts that encode a large set of proteins. Dystrophin represents approximately 0.002% of total striated muscle protein and localizes to triadic junctions in skeletal muscle, where it is thought to influence calcium ion homeostasis and force transmission. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHC |
| WB:1:1,000 IHC:1:50-1:200 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | BMD antibody CMD3B antibody DMD antibody DMD_HUMAN antibody Duchenne muscular dystrophy protein antibody Dystrophin antibody Muscular dystrophy Duchenne and Becker types antibody |
|---|---|
| Molecular Weight(MW) | 427 kDa |
| Cellular Localization | Cell membrane, Cytoplasm, Cell junction. |
Application
Fig1: Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue using anti-Dystrophin antibody. Counter stained with hematoxylin.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-Dystrophin antibody. Counter stained with hematoxylin.| Positive Control | Mouse skeletal muscle tissue, mouse brain tissue. |
|---|---|
| Application Notes | WB:1:1,000 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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