Anti-Integrin alpha 3a antibody [29A3]

• 产品名称

  Anti-Integrin alpha 3a抗体[29A3]

• 描述

  小鼠单克隆抗体[29A3] to Integrin alpha 3a

• 宿主

  Mouse

• 特异性

  29A3 recognizes specifically the cytoplasmic domain of integrin subunit α3A which is present in the basal cell layer in skin, glomeruli, Bowman’s capsules and distal tubuli in kidney, all vascular and capillary endothelia in brain, heart and skin, and vascular smooth muscle cells in heart.

• 经测试应用

  适用于: IHC-Frmore details

• 种属反应性

  与反应: Human
  

• 免疫原

  Synthetic peptide corresponding to Integrin alpha 3a conjugated to keyhole limpet haemocyanin.
  Database link: P26006

  Run BLAST with Run BLAST with 

• 表位

  Cytoplasmic domain of a3A Integrin. Phospho-epitope.

• 常规说明

  Background
  Integrins are a family of heterodimeric membrane glycoproteins consisting of non-covalently associated α and β subunits. More than 18 α and 8 β subunits with numerous splice variant isoforms have been identified in mammals. In general, integrins function as receptors for extracellular matrix proteins. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migRation and apoptosis. For integrin subunits α3 and α6, two cytoplasmic variants, A and B, have been identified.

  Source
  29A3 is a Mouse monoclonal IgG1, κ antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with a synthetic peptide corresponding to the cytoplasmic domain of the integrin subunit α3A including an additional N-terminal cysteine (CRTRALYEAKRQKAEMKSQPSETERLTDDY) coupled to keyhole limpet hemocyanin.

  Formulation: Each vial contains 100 ul 1 mg/ml purified monoclonal antibody in PBS containing 0.09% sodium azide.

  
  

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• 形式

  Liquid

• 存放说明

  Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

• 存储溶液

  Preservative: 0.09% Sodium azide
  Constituent: PBS

• 纯度

  Protein G purified

• Primary antibody说明

  The integrins, finally, form a large family of glycosylated transmembrane proteins that act as dimers of an alpha and a beta subunit in interconnecting the cytoskeleton and the extracellular matrix.

• 克隆

  单克隆

• 克隆编号

  29A3

• 骨髓瘤

  Sp2/0

• 同种型

  IgG1

• 轻链类型

  kappa

The Abpromise guarantee

Abpromise™承诺保证使用ab8985于以下的经测试应用

“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

• 数据库链接

• Entrez Gene: 3675 Human

• SwissProt: P26006 Human

• 别名

• MSK18 antibody

• VL3A antibody

• CD49C antibody

• GAPB3 antibody

• ITGA3 antibody

• 

  Immunohistochemistry (Frozen sections) - Anti-Integrin alpha 3a antibody [29A3] (ab8985)

  Immunohistochemistry on frozen section of human kidney