Anti-GFR alpha 3/GFRA3抗体
参阅全部 GFR alpha 3/GFRA3 一抗
兔多克隆抗体to GFR alpha 3/GFRA3
Rabbit
适用于: IHC-P, WBmore details
与反应: Mouse
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
(Peptide available as ab6100)
Members of the glial cell line-derived neurotrophic factor(GDNF) family including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphadidylinositol linked protein GFRa and Ret receptor tyrosine kinase GFRb. Following the findings of GFRa-1 and -2, a novel receptor in GFRa family was identified very recently from human and mouse and designated GFRa-3. GFRa-3 binds persephin, thus, persephin, GFRa-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.
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Liquid
Shipped at 4°C. Store at +4°C.
pH: 7.2
Preservative: 0.02% Sodium azide
DEAE-Chromatography
Members of the glial cell line-derived neurotrophic factor(GDNF) family including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphadidylinositol linked protein GFRa and Ret receptor tyrosine kinase GFRb. Following the findings of GFRa-1 and -2, a novel receptor in GFRa family was identified very recently from human and mouse and designated GFRa-3. GFRa-3 binds persephin, thus, persephin, GFRa-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.
多克隆
IgG
Abpromise™承诺保证使用ab8028于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P | Use a concentration of 10 µg/ml. | |
| WB | 1/500 - 1/1000. Predicted molecular weight: 43 kDa.Can be blocked with GFR alpha 3/GFRA3 peptide (ab6100). |
Entrez Gene: 14587 Mouse
SwissProt: O35118 Mouse
Unigene: 16520 Mouse
GDNFR-alpha-3 antibody
GDNFR3 antibody
GFR-alpha-3 antibody
GFRA3 antibody
GFRA3_HUMAN antibody
Glial cell line derived neurotrophic factor receptor alpha 3 antibody
GPI linked receptor antibody
OTTHUMP00000159486 antibody
OTTHUMP00000224020 antibody
GDNF family receptor alpha 3 antibody
GDNF family receptor alpha-3 antibody
GDNF receptor alpha-3 antibody
Western blot - Anti-GFR alpha 3/GFRA3 antibody (ab8028)
All lanes : Anti-GFR alpha 3/GFRA3 antibody (ab8028) at 1/500 dilution
Lane 1 : Crude cell membrane fractions of murine heart
Lane 2 : Crude cell membrane fractions of murine spleen
Lane 3 : Crude cell membrane fractions of murine kidney
Lane 4 : Crude cell membrane fractions of murine liver
Lane 5 : Crude cell membrane fractions of murine brain
Predicted band size: 43 kDa
Observed band size: 43 kDa
Western blot analysis of GFR alpha 3/GFRA3 in crude cell membrane fractions of
murine heart (H), spleen (S), kidney (K), liver (L), and brain (B), respectively, with ab8028 at 1/500 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFR alpha 3/GFRA3 antibody (ab8028)
Immunohistochemistry (Formalin-fixed paraffin embedded sections) of mouse kidney tissue labeling GFR alpha 3/GFRA3 with Anti-GFR alpha 3/GFRA3 antibody (ab8028) at 5μg/ml.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFR alpha 3/GFRA3 antibody (ab8028)
ab8028 at 10µg/ml staining GFR alpha 3/GFRA3 in mouse heart tissue by IHC-P.
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