Anti-SynGAP抗体
参阅全部 SynGAP 一抗
兔多克隆抗体to SynGAP
Rabbit
适用于: ICC/IF, IHC-Pmore details
与反应: Rat, Human
Recombinant fragment within Rat SynGAP aa 900-1200. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: Q9QUH6-2
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Liquid
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle.
Constituents: 99% PBS, 0.1% BSA
浓度
100 µg 浓度为 1 mg/ml
Immunogen affinity purified
Synaptic Ras GTPase Activating Protein (SynGAP) is a PDZ-domain interacting protein expressed almost exclusively in the brain. SynGAP has been shown to be a major component of postsynaptic density and associates with post synaptic density 95 kDa (PSD-95), a synaptic scaffold protein, and synaptic N-methyl-D-aspartate (NMDA) receptors. SynGAP Ras-GTPase activity has also been shown to be inhibited by phosphorylation by CaM kinase II, another abundant protein located in the postsynaptic density. It has been proposed that SynGAP may function as a negative regulator of MAP Kinase activation in the absence of active NMDA receptors.
多克隆
IgG
Abpromise™承诺保证使用ab3344于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ICC/IF | Use a concentration of 2 µg/ml. | |
| IHC-P | Use a concentration of 2 µg/ml. |
Entrez Gene: 8831 Human
Omim: 603384 Human
SwissProt: Q96PV0 Human
Unigene: 586264 Human
Unigene: 9908 Rat
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Immunocytochemistry/ Immunofluorescence - Anti-SynGAP antibody (ab3344)
Immunocytochemistry analysis of 4% paraformaldehyde-fixed 0.1% Triton™ X-100 permeabilized PC-12 cells staining synGAP with ab3344 at 2 µg/ml concentration and Goat anti-Rabbit IgG (H+L) Superclonal™ Secondary Antibody Alexa Fluor® 488 conjugate at 1:2000. Nuclei were stained with SlowFade® Gold Antifade Mountant with DAPI (blue), and F-actin stained with Alexa Fluor® 555 Rhodamine Phalloidin (red). Negative control is using no primary antibody control.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SynGAP antibody (ab3344)
Immunohistochemical anysis of paraffin-embedded human hear tissue staining synGAP with ab3344 at 1/100 dilution counterstained with hematoxylin and detected using HRP-conjugated secondary antibody. Negative control (left) has no primary antibody.
Immunocytochemistry/ Immunofluorescence - Anti-SynGAP antibody (ab3344)
Immunolocalization of SynGAP in rat hippocampal neurons using ab3344.
Immunocytochemistry/ Immunofluorescence - Anti-SynGAP antibody (ab3344)
Immunolocalization of SynGAP in rat hippocampal neurons using ab3344.
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