Anti-Interferon alpha/beta receptor 1 antibody - BSA and Azide free

• 产品名称

  Anti-Interferon alpha/beta receptor 1抗体- BSA and Azide free
  参阅全部 Interferon alpha/beta receptor 1 一抗

• 描述

  山羊多克隆抗体to Interferon alpha/beta receptor 1 - BSA and Azide free

• 宿主

  Goat

• 特异性

  Based on ELISA and immunoblotting, this antibody shows no cross-reactivity with recombinant human IFNGRI and IFNGRII.

• 经测试应用

  适用于: Flow Cyt, ELISA, Neutralising, WBmore details

• 种属反应性

  与反应: Human
  

• 免疫原

  Recombinant full length protein corresponding to Human Interferon alpha/beta receptor 1.
  Database link: P17181

• 常规说明

  Endotoxin level is < 10 ng/mg antibody as determined by the LAL (Limulus amebocyte lysate) method. This antibody was used as a detection antibody in sELISA and was paired with ab91466 as capture antibody. Abreview 24657.

  IFNAR1 is a member of the cytokine receptor superfamily which also includes receptors for interleukins, IFN gamma, ciliary neurotrophic factor, somatotrophin, erythropoietin, nerve growth factor, tumor necrosis factor, leukemia inhibitory factor, and oncostatin M. Some members of the family have an alpha chain with either low or high ligand binding affinity and at least one beta chain involved in signal transduction with either relatively low or no ligand binding affinity. Type I interferons, alpha and beta, induce a variety of effects on target cells including antiviral, antiproliferative, and immunomodulatory activities. The alpha and beta interferons compete to bind to a common cell surface receptor, while IFN gamma binds to a distinct receptor. IFNAR1 is very responsive to type I interferons and bind to IFN beta and IFN alpha subtypes. It is also functionally involved in signal transduction because of its association with the cytoplasmic tyrosine kinase JAK1. The type I interferons, alpha and beta, are produced by leukocytes (alpha subunits), fibroblasts (beta subtypes), lymphocytes (omega subtypes), and ruminant embryos (tau subtypes). Interferon receptors are generally found on most human cell types whatever their origin, even on cells poorly responsive to interferon. IFNAR1 is expressed on the cell surface in a variety of human cell lines.

  
  

  The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

  If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

• 形式

  Liquid

• 存放说明

  Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

• 存储溶液

  Constituent: PBS

• 无载体

  是

• 浓度

• 25 µg 浓度为 0.1 mg/ml

• 纯度

  Immunogen affinity purified

• 纯化说明

  Affinity isolated antigen specific antibody is obtained from goat anti-Interferon alpha/beta receptor 1 antiserum by immuno-specific purification which removes essentially all goat serum proteins, including immunoglobulins, which do not specifically bind to the peptide.

• Primary antibody说明

  IFNAR1 is a member of the cytokine receptor superfamily which also includes receptors for interleukins, IFN gamma, ciliary neurotrophic factor, somatotrophin, erythropoietin, nerve growth factor, tumor necrosis factor, leukemia inhibitory factor, and oncostatin M. Some members of the family have an alpha chain with either low or high ligand binding affinity and at least one beta chain involved in signal transduction with either relatively low or no ligand binding affinity. Type I interferons, alpha and beta, induce a variety of effects on target cells including antiviral, antiproliferative, and immunomodulatory activities. The alpha and beta interferons compete to bind to a common cell surface receptor, while IFN gamma binds to a distinct receptor. IFNAR1 is very responsive to type I interferons and bind to IFN beta and IFN alpha subtypes. It is also functionally involved in signal transduction because of its association with the cytoplasmic tyrosine kinase JAK1. The type I interferons, alpha and beta, are produced by leukocytes (alpha subunits), fibroblasts (beta subtypes), lymphocytes (omega subtypes), and ruminant embryos (tau subtypes). Interferon receptors are generally found on most human cell types whatever their origin, even on cells poorly responsive to interferon. IFNAR1 is expressed on the cell surface in a variety of human cell lines.

• 克隆

  多克隆

• 同种型

  IgG

The Abpromise guarantee

Abpromise™承诺保证使用ab10739于以下的经测试应用

“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

• 数据库链接

• Entrez Gene: 3454 Human

• Omim: 107450 Human

• SwissProt: P17181 Human

• Unigene: 529400 Human

• 别名

• AVP antibody

• Beta type antiviral protein antibody

• CRF2-1 antibody

• Cytokine receptor class-II member 1 antibody

• Cytokine receptor family 2 member 1 antibody

• IFN alpha REC antibody

• IFN alpha receptor antibody

• IFN alpha/beta Receptor alpha antibody

• IFN beta receptor antibody

• IFN Interferon-beta receptor antibody

• IFN-alpha/beta receptor 1 antibody

• IFN-R-1 antibody

• IFNAR antibody

• Ifnar1 antibody

• IFNBR antibody

• IFRC antibody

• INAR1_HUMAN antibody

• Interferon (alpha beta and omega) receptor 1 antibody

• interferon alpha and beta receptor subunit 1 antibody

• Interferon alpha/beta receptor 1 antibody

• Interferon alpha/beta receptor alpha chain antibody

• Interferon beta receptor 1 antibody

• interferon receptor 1 antibody

• Interferon-alpha receptor antibody

• Type I interferon receptor 1 antibody

• Alpha type antiviral protein antibody

• Antiviral protein, alpha-type antibody

• Antiviral protein, beta-type antibody