Anti-Drosophila FMR1 antibody [6A15]

• 产品名称

  Anti-Drosophila FMR1抗体[6A15]

• 描述

  小鼠单克隆抗体[6A15] to Drosophila FMR1

• 宿主

  Mouse

• 经测试应用

  适用于: ELISA, ICC/IF, IP, WBmore details

• 种属反应性

  与反应: Drosophila melanogaster
  不与反应: Human

• 免疫原

  Recombinant fragment (His-tag) corresponding to Drosophila melanogaster Drosophila FMR1. N-terminal His tag-dFMR1 (C-terminal 580aa).
  Database link: Q9NFU0

• 常规说明

  
  

  Fragile X syndrome is the most common inherited form of mental retardation. It is caused by loss of FMR1 gene activity due to either lack of expression or expression of a mutant form of the protein. In mammals, FMR1 is a member of a small protein family that consists of FMR1, FXR1, and FXR2. All three members bind RNA and contain sequence motifs that are commonly found in RNA-binding proteins, including two KH domains and an RGG box.The Drosophila genome contains a single gene homologous to the FXR family. dFMR1 is subjected to transcriptional and posttranscriptional regulation during development and it homomerizes, like its human counterpart. dFMR1 profile of expression recapitulates that of the human FXR protein family: it is highly enriched in muscles, in central nervous system and in gonads. In the larval brain, anti-dFMR1 also recognizes mushroom bodies, a centre that mediates learning and memory. These features make the fly an ideal system to analyse the role of the FXR family and to identify genes in the FMRP pathway.

  
  

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• 形式

  Liquid

• 存放说明

  Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

• 存储溶液

  Preservative: 0.1% Sodium azide
  Constituent: PBS

• 浓度

• 100 µl 浓度为 1 mg/ml

• 纯度

  Protein A purified

• 纯化说明

  Protein A purified from tissue culture supernatant.

• Primary antibody说明

  Fragile X syndrome is the most common inherited form of mental retardation. It is caused by loss of FMR1 gene activity due to either lack of expression or expression of a mutant form of the protein. In mammals, FMR1 is a member of a small protein family that consists of FMR1, FXR1, and FXR2. All three members bind RNA and contain sequence motifs that are commonly found in RNA-binding proteins, including two KH domains and an RGG box.The Drosophila genome contains a single gene homologous to the FXR family. dFMR1 is subjected to transcriptional and posttranscriptional regulation during development and it homomerizes, like its human counterpart. dFMR1 profile of expression recapitulates that of the human FXR protein family: it is highly enriched in muscles, in central nervous system and in gonads. In the larval brain, anti-dFMR1 also recognizes mushroom bodies, a centre that mediates learning and memory. These features make the fly an ideal system to analyse the role of the FXR family and to identify genes in the FMRP pathway.

• 克隆

  单克隆

• 克隆编号

  6A15

• 骨髓瘤

  Sp2/0

• 同种型

  IgG1

The Abpromise guarantee

Abpromise™承诺保证使用ab10299于以下的经测试应用

“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

• 数据库链接

• Entrez Gene: 37528 Drosophila melanogaster

• SwissProt: Q9NFU0 Drosophila melanogaster

• 别名

  hide

• Drosophila fragile X mental retardation protein antibody

• fragile X mental retardation protein antibody

• dFMR antibody

• dFMR1 antibody

• dFXR antibody