| 存储条件 |
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| Product Name | PAX6 [SD081-03] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | AN 2 antibody AN antibody AN2 antibody Aniridia type II protein antibody D11S812E antibody FVH1 antibody KIAA0552 antibody Leucine zipper putative tumor suppressor 3 antibody LZTS3 antibody MGC17209 antibody MGDA antibody Oculorhombin antibody Paired box 6 antibody Paired box gene 6 (aniridia keratitis) antibody Paired Box Gene 6 antibody Paired box homeotic gene 6 antibody Paired box protein Pax-6 antibody Paired box protein Pax6 antibody PAX 6 antibody PAX6 antibody PAX6_HUMAN antibody ProSAP-interacting protein 1 antibody PROSAPIP1 antibody Sey antibody WAGR antibody |
| Product description | Pax genes contain paired domains with strong homology to genes in Drosophila which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHCFC |
| WB:1:1,000-1:5,000 FC:1:50-1:100 IHC:1:50-1:200 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | AN 2 antibody AN antibody AN2 antibody Aniridia type II protein antibody D11S812E antibody FVH1 antibody KIAA0552 antibody Leucine zipper putative tumor suppressor 3 antibody LZTS3 antibody MGC17209 antibody MGDA antibody Oculorhombin antibody Paired box 6 antibody Paired box gene 6 (aniridia keratitis) antibody Paired Box Gene 6 antibody Paired box homeotic gene 6 antibody Paired box protein Pax-6 antibody Paired box protein Pax6 antibody PAX 6 antibody PAX6 antibody PAX6_HUMAN antibody ProSAP-interacting protein 1 antibody PROSAPIP1 antibody Sey antibody WAGR antibody |
|---|---|
| Molecular Weight(MW) | 47 kDa |
| Cellular Localization | Nucleus. |
Application
Fig1: Western blot analysis of PAX6 on mouse eyes lysates using anti-PAX6 antibody at 1/1,000 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded rat eyes tissue using anti-PAX6 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded mouse eyes tissue using anti-PAX6 antibody. Counter stained with hematoxylin.
Application
Fig4: Flow cytometric analysis of SH-SY-5Y cells with PAX6 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the ssecondary antibody| Positive Control | Mouse eyes tissue, rat eyes tissue. |
|---|---|
| Application Notes | WB:1:1,000-1:5,000 FC:1:50-1:100 IHC:1:50-1:200 |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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