| 存储条件 |
|---|
| Product Name | Stromal interaction molecule 1 [SD0814] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | D11S4896E antibody GOK antibody OTTHUMP00000164512 antibody OTTHUMP00000229140 antibody OTTHUMP00000230742 antibody SIM antibody STIM 1 antibody STIM1 antibody Stim1 stromal interaction molecule 1 antibody STIM1_HUMAN antibody STIM1L antibody Stromal interaction molecule 1 antibody |
| Product description | Ca2+ influx is essential for a variety of cellular functions including, secretion and transcription. Stromal interaction molecule 1 (Stim1) is a ubiquitously expressed cell surface transmembrane glycoprotein that plays a role in medi-ating Ca2+ influx following the depletion of intracellular Ca2+ stores. Stim1 functions in the endoplasmic reticulum (ER) where it acts as a Ca2+ sensor via its EF-hand domain which causes large conformational changes. When Ca2+ levels drop, Stim1 translocates from the ER to the plasma membrane, where it activates the Ca2+ release-activated Ca2+ (CRAC) channel subunit, TMEM142A/Orai1. Stim2 is a potent inhibitor of Stim1-mediated store-operated calcium (SOC) entry. Stim1 is implicated in tumor growth suppression and stromal-hematopoietic cell interactions. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBIHCIP |
| WB:1:1,000 IHC:1:50-1:200 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Alternative Names | D11S4896E antibody GOK antibody OTTHUMP00000164512 antibody OTTHUMP00000229140 antibody OTTHUMP00000230742 antibody SIM antibody STIM 1 antibody STIM1 antibody Stim1 stromal interaction molecule 1 antibody STIM1_HUMAN antibody STIM1L antibody Stromal interaction molecule 1 antibody |
|---|---|
| Molecular Weight(MW) | 100 kDa |
| Cellular Localization | Cell membrane, Endoplasmic reticulum membrane, Cytoplasm, Sarcoplasmic reticulum. |
Application
Fig1: Western blot analysis of STIM1 on different lysates using anti-STIM1 antibody at 1/1,000 dilution. Positive control: Lane 1: K562 Lane 2: HepG2
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-STIM1 antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-STIM1 antibody. Counter stained with hematoxylin.| Positive Control | K562, HepG2, human spleen tissue, mouse testis tissue. |
|---|---|
| Application Notes | WB:1:1,000 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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