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| Product Name | ZEB1 [A2-D8] |
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| Antibody Type | Primary Antibodies |
| Antigen Alias | AREB 6 antibody AREB6 antibody BZP antibody Delta crystallin enhancer binding factor 1 antibody DELTA EF1 antibody FECD6 antibody MGC133261 antibody Negative regulator of IL 2 antibody Negative regulator of IL2 antibody NIL 2 A antibody NIL 2 A zinc finger protein antibody NIL 2A antibody NIL-2-A zinc finger protein antibody NIL2A antibody Posterior polymorphous corneal dystrophy 3 antibody PPCD3 antibody Represses interleukin 2 expression antibody TCF 8 antibody TCF-8 antibody TCF8 antibody Transcription factor 8 (represses interleukin 2 expression) antibody Transcription factor 8 antibody ZEB 1 antibody ZEB antibody ZEB1 antibody ZEB1_HUMAN antibody ZFHEP antibody ZFHX 1A antibody ZFHX1A antibody Zinc finger E box binding homeobox 1 antibody Zinc finger E-box-binding homeobox 1 antibody Zinc finger homeodomain enhancer binding protein antibody |
| Product description | ZEB1 is a non-receptor transcription factor analogous to the Drosophila ZFH-1 protein. ZEB1 contains two separate zinc finger domains (ZD1 and ZD2), which are essential for DNA binding and repression, and a homeodomain, which is not. ZEB1 also contains three repression domains, two of which flank ZD1, and a third located between HD and ZD2. ZEB1 represses transcription by site competition and enhancer silencing mechanisms, as well as by interacting with corepressors through its repression domains. Interaction of ZEB1 with the TSHβ gene T3-response element may play a role in the modification of gene-specific regulation by thyroid hormones. In the embryo, ZEB1 is primarily expressed in the mesoderm, but changes in the level of expression during tissue maturation suggest a role for ZEB1 in the early histogenesis of mesodermal tissues. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
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| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIHCFC |
| WB:1:500-1:1,000 IHC:1:100-1:500 FC:1:100-1:200 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | AREB 6 antibody AREB6 antibody BZP antibody Delta crystallin enhancer binding factor 1 antibody DELTA EF1 antibody FECD6 antibody MGC133261 antibody Negative regulator of IL 2 antibody Negative regulator of IL2 antibody NIL 2 A antibody NIL 2 A zinc finger protein antibody NIL 2A antibody NIL-2-A zinc finger protein antibody NIL2A antibody Posterior polymorphous corneal dystrophy 3 antibody PPCD3 antibody Represses interleukin 2 expression antibody TCF 8 antibody TCF-8 antibody TCF8 antibody Transcription factor 8 (represses interleukin 2 expression) antibody Transcription factor 8 antibody ZEB 1 antibody ZEB antibody ZEB1 antibody ZEB1_HUMAN antibody ZFHEP antibody ZFHX 1A antibody ZFHX1A antibody Zinc finger E box binding homeobox 1 antibody Zinc finger E-box-binding homeobox 1 antibody Zinc finger homeodomain enhancer binding protein antibody |
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| Molecular Weight(MW) | 124 kDa |
| Cellular Localization | Nucleus. |
| SwissProt ID | P37275 |
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Application
Fig1: Western blot analysis of ZEB1 on human ZEB1 recombinant protein using anti-ZEB1 antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of ZEB1 on HEK293 (1) and ZEB1-hIgGFc transfected HEK293 (2) cell lysate using anti-ZEB1 antibody at 1/1,000 dilution.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human rectum cancer tissue using anti-ZEB1 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue using anti-ZEB1 antibody. Counter stained with hematoxylin.
Application
Fig5: Flow cytometric analysis of Hela cells with ZEB1 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).| Positive Control | Human ZEB1 recombinant protein, ZEB1-hIgGFc transfected HEK293 cell lysate, Hela, human cervical cancer tissue, human rectum cancer tissue. |
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| Application Notes | WB:1:500-1:1,000 IHC:1:100-1:500 FC:1:100-1:200 |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide. |
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