| 存储条件 |
|---|
| Product Name | VAV1 [C10-E11] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Oncogene vav antibody p95Vav antibody Proto-oncogene vav antibody Protooncogene vav antibody VAV 1 antibody VAV 1 oncogene antibody VAV antibody Vav proto oncogene antibody VAV_HUMAN antibody VAV1 antibody |
| Product description | The Vav gene was originally identified on the basis of its oncogenic activation during the course of gene transfer assays. The major translational product of the Vav proto-oncogene has been identified as a protein containing an array of structural motifs. This protein, known as Vav, Vav1 or p95Vav, contains an N-terminal helix-loop-helix domain and a leucine zipper motif similar to that of Myc family proteins that, if deleted, causes oncogenic activation. In addition, Vav contains an SH2 domain, which could indicate its role as a substrate for tyrosine kinases. Expression of Vav is limited exclusively to cells of hematopoietic origin, including those of the erythroid, lymphoid and myeloid lineages. These results suggest that Vav may represent a new type of signal transduction molecule involved in the transduction of tyrosine phosphorylation signaling into transcriptional events. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBFC |
| WB:1:500-1:1,000 FC:1:100-1:200 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | Oncogene vav antibody p95Vav antibody Proto-oncogene vav antibody Protooncogene vav antibody VAV 1 antibody VAV 1 oncogene antibody VAV antibody Vav proto oncogene antibody VAV_HUMAN antibody VAV1 antibody |
|---|---|
| Molecular Weight(MW) | 98 kDa |
| Cellular Localization | Cytosol. |
| SwissProt ID | P15498 |
|---|
Application
Fig1: Western blot analysis of VAV1 on Jurkat cell lysate using anti-VAV1 antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of VAV1 on human VAV1 recombinant protein using anti-VAV1 antibody at 1/1,000 dilution.
Application
Fig3: Western blot analysis of VAV1 on HEK293 (1) and VAV1-hIgGFc transfected HEK293 (2) cell lysate using anti-VAV1 antibody at 1/1,000 dilution.
Application
Fig4: Flow cytometric analysis of Hela cells with VAV1 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).| Positive Control | Jurkat, human VAV1 recombinant protein, VAV1-hIgGFc transfected HEK293 cell lysate, Hela. |
|---|---|
| Application Notes | WB:1:500-1:1,000 FC:1:100-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide. |
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