cdk8 antibody CDK8 protein kinase antibody CDK8_HUMAN antibody Cell Division Kinase 8 antibody Cell division protein kinase 8 antibody Cyclin Dependent kinase 8 antibody Cyclin-dependent kinase 8 antibody K35 antibody Mediator complex subunit cdk8 antibody Mediator of RNA polymerase II transcription subunit cdk8 antibody Protein kinase K35 antibody
Product description
Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks). Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Another family of proteins, Cdk inhibitors, also plays a role in regulating cell cycle by binding to cyclin-Cdk complexes and modulating their activity. Several Cdk proteins have been identified, including Cdk2-Cdk8, PCTAIRE-1–3, PITALRE and PITSLRE. Large complexes containing Cdk8, cyclin C and the large subunit of RNA polymerase II have been identified. Cdk8 is thought to regulate RNA polymerase II function in conjunction with cyclin C. Cdk8 has been demonstrated to function as a transcriptional activator when fused to the DNA binding domain of GAL4.
Immunogen
recombinant protein
Key Feature
Clonality
Monoclonal
Isotype
IgG
Host Species
Recombinant rabbit
Tested Applications
WBIP
WB:1:1,000-1:2,000
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Unpurified
Target Information
Alternative Names
cdk8 antibody CDK8 protein kinase antibody CDK8_HUMAN antibody Cell Division Kinase 8 antibody Cell division protein kinase 8 antibody Cyclin Dependent kinase 8 antibody Cyclin-dependent kinase 8 antibody K35 antibody Mediator complex subunit cdk8 antibody Mediator of RNA polymerase II transcription subunit cdk8 antibody Protein kinase K35 antibody
