CHTD2 antibody FLJ21885 antibody KIAA0733 antibody MAP3K7IP2 antibody Mitogen activated protein kinase kinase kinase 7 interacting protein 2 antibody Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 antibody OTTHUMP00000040125 antibody TAB 2 antibody TAB-2 antibody Tab2 antibody TAB2_HUMAN antibody TAK1 binding protein 2 antibody TAK1-binding protein 2 antibody TGF beta activated kinase 1/MAP3K7 binding protein 2 antibody TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 antibody TGF-beta-activated kinase 1-binding protein 2 antibody
Product description
The TAK1 binding proteins, TAB1, TAB2 and TAB3, interact with the MAPKKK TAK1 in response to various stimuli. TAB1 activates TAK1 in TGFβ mediated signaling. TAB1 also plays a central role in a p38α activation pathway that is independent of MAPKK. In response to proinflammatory signals, TAB2 complexes with TRAF6 and TAK1, leading to translocation of the complex from the membrane to the cytosol and the subsequent activation of TAK1. When overexpressed, TAB3 activates both NFkB and AP-1 transcription factors. In response to TNFα or IL-1, TAK1 complexes with TAB1 and TAB2 or with TAB1 and TAB3 to yield two distinct complexes.
Immunogen
Recombinant protein
Key Feature
Clonality
Monoclonal
Isotype
IgG1
Host Species
Mouse
Tested Applications
WBFC
WB:1:500-1:1,000 FC:1:100-1:200
Species Reactivity
Human
Concentration
2mg/ml
Target Information
Alternative Names
CHTD2 antibody FLJ21885 antibody KIAA0733 antibody MAP3K7IP2 antibody Mitogen activated protein kinase kinase kinase 7 interacting protein 2 antibody Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 antibody OTTHUMP00000040125 antibody TAB 2 antibody TAB-2 antibody Tab2 antibody TAB2_HUMAN antibody TAK1 binding protein 2 antibody TAK1-binding protein 2 antibody TGF beta activated kinase 1/MAP3K7 binding protein 2 antibody TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 antibody TGF-beta-activated kinase 1-binding protein 2 antibody
Fig1: Western blot analysis of TAB2 on HEK293 (1) and TAB2-hIgGFc transfected HEK293 (2) cell lysate using anti-TAB2 antibody at 1/1,000 dilution.
Application
Fig2: Flow cytometric analysis of HL-60 cells with TAB2 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; purple).
