| 存储条件 |
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| Product Name | CRTC3 [G8-A9] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | CREB regulated transcription coactivator 3 antibody CREB-regulated transcription coactivator 3 antibody CRTC 3 antibody CRTC3 antibody CRTC3_HUMAN antibody FLJ21868 antibody TORC 3 antibody TORC-3 antibody TORC3 antibody Transducer of CREB protein 3 antibody Transducer of regulated cAMP response element binding protein (CREB) 3 antibody Transducer of regulated cAMP response element binding protein 3 antibody Transducer of regulated cAMP response element-binding protein 3 antibody Transducer of regulated CREB protein 3 antibody |
| Product description | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR) .Tissue specificity: Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBICCIHC |
| WB:1:500-1:2,000 ICC:1:100-1:500 IHC:1:100-1:500 | |
| Species Reactivity | HumanMonkey |
| Concentration | 2mg/ml |
| Alternative Names | CREB regulated transcription coactivator 3 antibody CREB-regulated transcription coactivator 3 antibody CRTC 3 antibody CRTC3 antibody CRTC3_HUMAN antibody FLJ21868 antibody TORC 3 antibody TORC-3 antibody TORC3 antibody Transducer of CREB protein 3 antibody Transducer of regulated cAMP response element binding protein (CREB) 3 antibody Transducer of regulated cAMP response element binding protein 3 antibody Transducer of regulated cAMP response element-binding protein 3 antibody Transducer of regulated CREB protein 3 antibody |
|---|---|
| Molecular Weight(MW) | 68kDa, additional band 43kDa |
| Cellular Localization | Cytoplasm. Nucleus. |
| SwissProt ID | Q6UUV7 |
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Application
Fig1: Western blot analysis of CRTC3 on different cell lysates using anti-CRTC3 antibody at 1/1,000 dilution. Positive control: Lane 1: Hela Lane 2: Jurkat Lane 3: Cos7 Lane 4: MCF-7
Application
Fig2: ICC staining CRTC3 (green) and actin filaments (red) in NTERA-2 cells. Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti-CRTC3 antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissue using anti-CRTC3 antibody. Counter stained with hematoxylin.
Application
Application
Application
Fig6: Immunohistochemical analysis of paraffin-embedded human esophagus cancer tissue using anti-CRTC3 antibody. Counter stained with hematoxylin.| Application Notes | WB:1:500-1:2,000 ICC:1:100-1:500 IHC:1:100-1:500 |
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| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide. |
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