| 存储条件 |
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| Product Name | SRY [E9-G4] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Essential protein for sex determination in human males antibody Sex determining region on Y antibody Sex determining region protein antibody Sex determining region Y antibody Sex-determining region Y protein antibody sox21b antibody SRXX1 antibody SRXY1 antibody SRY 1 antibody SRY antibody SRY_HUMAN antibody Sry1 antibody Sry3BI antibody SRYGENE antibody TDF antibody TDY antibody Testis determining factor antibody Testis Determining Factor on Y antibody Testis-determining factor antibody Transcription factor Sox-21-B antibody |
| Product description | SRY (sex-determining region Y protein) is a tran-scriptional activator required for male sex determination in mammals. This protein, also referred to as testis-determining factor (TDF), is an HMG box protein that initiates the formation of testis from undifferentiated gonad. The DNA-binding activity of SRY is required for normal testis formation. This DNA-binding activity is thought to be regulated by PKA, which phosphorylates SRY in vivo. Mutations in SRY have been associated with 46,XY gonadal dysgenesis, in which the gonads fail to develop in XY phenotypic females. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIHCFC |
| WB:1:500-1:1,000 IHC:1:100-1:500 FC:1:100-1:200 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | Essential protein for sex determination in human males antibody Sex determining region on Y antibody Sex determining region protein antibody Sex determining region Y antibody Sex-determining region Y protein antibody sox21b antibody SRXX1 antibody SRXY1 antibody SRY 1 antibody SRY antibody SRY_HUMAN antibody Sry1 antibody Sry3BI antibody SRYGENE antibody TDF antibody TDY antibody Testis determining factor antibody Testis Determining Factor on Y antibody Testis-determining factor antibody Transcription factor Sox-21-B antibody |
|---|---|
| Molecular Weight(MW) | 40 kDa |
| Cellular Localization | Nucleus speckle. Cytoplasm. |
| SwissProt ID | Q05066 |
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Application
Fig1: Western blot analysis of SRY on human SRY recombinant protein using anti-SRY antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of SRY on NTERA-2 cell lysate using anti-SRY antibody at 1/1,000 dilution.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human cervical cancer tissue using anti-SRY antibody. Counter stained with hematoxylin.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissue using anti-SRY antibody. Counter stained with hematoxylin.
Application
Fig5: Flow cytometric analysis of HepG2 cells with SRY antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).| Positive Control | Human SRY recombinant protein, NTERA-2, human cervical cancer tissue, human ovarian cancer tissue, HepG2. |
|---|---|
| Application Notes | WB:1:500-1:1,000 IHC:1:100-1:500 FC:1:100-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide. |
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