Fn14, the TWEAK receptor, is a recently identified member of the TNF receptor superfamily and is expressed on smooth muscle cells and endothelial cells. It is a weak inducer of apoptosis and promotes angiogenesis. Fn14 is a type 1 membrane protein. It associates with TRAF1 and TRAF2, and may modulate cellular adhesion to matrix proteins. Fn14 is highly expressed in heart, placenta and kidney, and moderately expressed in lung, skeletal muscle and pancreas. It is the smallest member of the TNF receptor (TNFR) superfamily described to date, and signals via recruitment of several different TNFR-associated factors.
Fig1: Western blot analysis of TWEAKR on different lysates using anti-TWEAKR antibody at 1/1,000 dilution. Positive control: Lane 1: NIH/3T3 Lane 2: C2C12
Application
Fig2: Immunohistochemical analysis of paraffin-embedded mouse uterus tissue using anti-TWEAKR antibody. Counter stained with hematoxylin.
Positive Control
NIH/3T3, C2C12, mouse uterus tissue.
Application Notes
WB:1:500-1:1,000 IHC:1:50-1:200
Additional Information
Form
Liquid
Storage Instructions
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
