| 存储条件 |
|---|
| Product Name | PRKACG [B3-E4] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | BDPLT19 antibody cAMP dependent protein kinase alpha catalytic subunit antibody cAMP dependent protein kinase beta catalytic subun antibody cAMP dependent protein kinase catalytic subunit alpha antibodycAMP dependent protein kinase catalytic subunit beta antibody cAMP-dependent protein kinase catalytic beta subunit isoform 4ab antibody cAMP-dependent protein kinase catalytic subunit alpha, isoform 1 antibody Cs antibody KAPG antibody PKA antibody PKA C alpha antibody PKA C beta antibody PKA C gamma antibody PKACA antibody PKACB antibody PKACg antibody PPNAD4 antibody PRKACA antibody PRKACB antibody PRKACG antibody Protein kinase A catalytic subunit antibody Protein kinase A catalytic subunit alpha antibody Protein kinase A catalytic subunit beta antibody Protein kinase cAMP dependent catalytic alpha antibody Protein kinase cAMP dependent catalytic beta antibody Protein kinase cAMP dependent catalytic beta isoform a antibody Protein kinase cAMP dependent catalytic beta isoform b antibody Protein kinase cAMP dependent catalytic gamma antibody protein kinase cAMP-activated catalytic subunit alpha antibody protein kinase cAMP-activated catalytic subunit gamma antibody protein kinase, cAMP-dependent, alpha catalytic subunit antibody protein kinase, cAMP-dependent, beta catalytic subunit antibody protein kinase, cAMP-dependent, gamma catalytic subunit antibody Serine (threonine) protein kinase antibody serine(threonine) protein kinase antibody |
| Product description | Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme resulting in release of active catalytic subunits. Three catalytic (C) subunits have been identified, designated PKAα cat (Cα), PKAβ cat (Cβ) and PKAγ cat (Cγ). Each subunit represents specific gene products. PKAα cat and PKAβ cat are closely related (93% amino acid sequence similarity), whereas PKAγ cat displays 83% and 79% similarity to PKAα cat and PKAβ cat, respectively. Activation of transcription upon elevation of cAMP levels results from translocation of PKA to the nucleus where it phosphorylates the transcription factor cAMP response element binding protein (CREB) on Serine 133, which in turn leads to TFIIB binding to TATA-box-binding protein TBP1, thus linking phospho-CREB to the Pol II transcription initiation complex. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIHCFC |
| WB:1:500-1:1,000 IHC:1:100-1:500 FC:1:100-1:200 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | BDPLT19 antibody cAMP dependent protein kinase alpha catalytic subunit antibody cAMP dependent protein kinase beta catalytic subun antibody cAMP dependent protein kinase catalytic subunit alpha antibodycAMP dependent protein kinase catalytic subunit beta antibody cAMP-dependent protein kinase catalytic beta subunit isoform 4ab antibody cAMP-dependent protein kinase catalytic subunit alpha isoform 1 antibody Cs antibody KAPG antibody PKA antibody PKA C alpha antibody PKA C beta antibody PKA C gamma antibody PKACA antibody PKACB antibody PKACg antibody PPNAD4 antibody PRKACA antibody PRKACB antibody PRKACG antibody Protein kinase A catalytic subunit antibody Protein kinase A catalytic subunit alpha antibody Protein kinase A catalytic subunit beta antibody Protein kinase cAMP dependent catalytic alpha antibody Protein kinase cAMP dependent catalytic beta antibody Protein kinase cAMP dependent catalytic beta isoform a antibody Protein kinase cAMP dependent catalytic beta isoform b antibody Protein kinase cAMP dependent catalytic gamma antibody protein kinase cAMP-activated catalytic subunit alpha antibody protein kinase cAMP-activated catalytic subunit gamma antibody protein kinase cAMP-dependent alpha catalytic subunit antibody protein kinase cAMP-dependent beta catalytic subunit antibody protein kinase cAMP-dependent gamma catalytic subunit antibody Serine (threonine) protein kinase antibody serine(threonine) protein kinase antibody |
|---|---|
| Molecular Weight(MW) | 40 kDa |
| Cellular Localization | Cytosol. Nucleus. |
| SwissProt ID | P22612 |
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Application
Fig1: Western blot analysis of PRKACG on human PRKACG recombinant protein using anti-PRKACG antibody at 1/1,000 dilution.
Application
Fig2: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-PRKACG antibody. Counter stained with hematoxylin.
Application
Fig3: Immunohistochemical analysis of paraffin-embedded human rectum cancer tissue using anti-PRKACG antibody. Counter stained with hematoxylin.
Application
Fig4: Flow cytometric analysis of MCF-7 cells with PRKACG antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).| Positive Control | Human PRKACG recombinant protein, human liver cancer tissue, human rectum cancer tissue, MCF-7. |
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| Application Notes | WB:1:500-1:1,000 IHC:1:100-1:500 FC:1:100-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide. |
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