hSMAD6 antibody MAD homolog 6 antibody MADH6 antibody MADH7 antibody Mothers against decapentaplegic homolog 6 antibody Mothers against DPP homolog 6 antibody SMAD 6 antibody SMAD family member 6 antibody SMAD mothers against DPP homolog 6 antibody Smad6 antibody SMAD6_HUMAN antibody
Product description
Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad) have been implicated as downstream effectors of TGFβ/BMP signaling. Smad1 (also designated Madr1 or JV4-1), Smad5 and mammalian Smad8 (also designated Smad9 or MADH6) are effectors of BMP2 and BMP4 function while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGFβ and activin-mediated growth modulation (2-5,8). Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGFβ signaling by interfering with TGFβ-mediated phosphorylation of other Smad family members.
Immunogen
Recombinant protein
Key Feature
Clonality
Monoclonal
Isotype
IgG1
Host Species
Mouse
Tested Applications
WB
WB:1:500-1:1,000
Species Reactivity
Human
Concentration
2mg/ml
Purification
Unpurified
Target Information
Alternative Names
hSMAD6 antibody MAD homolog 6 antibody MADH6 antibody MADH7 antibody Mothers against decapentaplegic homolog 6 antibody Mothers against DPP homolog 6 antibody SMAD 6 antibody SMAD family member 6 antibody SMAD mothers against DPP homolog 6 antibody Smad6 antibody SMAD6_HUMAN antibody
Fig1: Western blot analysis of SMAD6 on different cell lysates using anti-SMAD6 antibody at 1/1,000 dilution. Positive control： Lane1: A431 Lane2: A431 Lane3: Hela Lane4: Jurkat
Positive Control
A431, Hela, Jurkat.
Application Notes
WB:1:500-1:1,000
Additional Information
Form
Liquid
Storage Instructions
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
