| 存储条件 |
|---|
| Product Name | PTH1R [A5-D2] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MGC138426 antibody MGC138452 antibody Parathyroid hormone 1 receptor antibody Parathyroid hormone/parathyroid hormone related peptide receptor antibody Parathyroid hormone/parathyroid hormone related protein receptor antibody Parathyroid hormone/parathyroid hormone-related peptide receptor antibody PTH receptor antibody PTH/PTHr receptor antibody PTH/PTHrP receptor antibody PTH/PTHrP type I receptor antibody PTH1 receptor antibody PTH1R antibody PTH1R_HUMAN antibody PTHR 1 antibody PTHR antibody PTHR1 antibody |
| Product description | Parathyroid hormone (PTH), which is also designated parathyrin, is an 84 amino acid single chain peptide that functions to regulate calcium metabolism by raising blood levels of calcium through various mechanisms. Parathyroid hormone-related protein (PTH-rP) is an autocrine factor that is structurally related to PTH yet, unlike PTH, which is synthesized only by the parathyroid cells, PTH-rP is synthesized by several cell types. PTH-rP regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Isolated from the culture medium of a human lung cancer cell line, PTH-rP produces PTH-like effects that are characterized as humoral hypercalcemia of malignancy. PTH and PTH-rP are both regulated by vitamin D and steroid hormones and preferentially bind to specific PTH/PTH-rP receptors, then activate adenylate cyclase or PLC β via PKC activation. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBICCIHC |
| WB:1:500-1:1,000 ICC:1:50-1:200 IHC:1:100-1:500 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | MGC138426 antibody MGC138452 antibody Parathyroid hormone 1 receptor antibody Parathyroid hormone/parathyroid hormone related peptide receptor antibody Parathyroid hormone/parathyroid hormone related protein receptor antibody Parathyroid hormone/parathyroid hormone-related peptide receptor antibody PTH receptor antibody PTH/PTHr receptor antibody PTH/PTHrP receptor antibody PTH/PTHrP type I receptor antibody PTH1 receptor antibody PTH1R antibody PTH1R_HUMAN antibody PTHR 1 antibody PTHR antibody PTHR1 antibody |
|---|---|
| Molecular Weight(MW) | 66 kDa |
| Cellular Localization | Cell membrane. |
| SwissProt ID | Q03431 |
|---|
Application
Fig1: Western blot analysis of PTH1R on PTH1R-hIgGFc transfected HEK293 cell lysate using anti-PTH1R antibody at 1/1,000 dilution.
Application
Fig2: ICC staining PTH1R (green) in SK-BR-3 cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig3:Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-PTH1R antibody. Counter stained with hematoxylin.| Positive Control | PTH1R-hIgGFc transfected HEK293 cell lysate, SK-BR-3, human kidney tissue. |
|---|---|
| Application Notes | WB:1:500-1:1,000 ICC:1:50-1:200 IHC:1:100-1:500 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide. |
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