| 存储条件 |
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| Product Name | TRIP6 [G1-H4] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MGC10556 antibody MGC10558 antibody MGC29959 antibody MGC3837 antibody MGC4423 antibody OIP-1 antibody OIP1 antibody OPA interacting protein 1 antibody OPA-interacting protein 1 antibody Thyroid hormone receptor interactor 6 antibody Thyroid receptor interacting protein 6 antibody Thyroid receptor-interacting protein 6 antibody TR-interacting protein 6 antibody TRIP-6 antibody Trip6 antibody TRIP6_HUMAN antibody TRIP6i2 antibody ZRP 1 antibody ZRP-1 antibody Zyxin-related protein 1 antibody |
| Product description | Zyxin is a LIM domain-containing, zinc finger domain-containing, SH3 ligand-containing phosphoprotein that localizes to focal adhesion plaques and actin filament bundles. Thyroid receptor interacting protein 6 (TRIP6) is a Zyxin-related protein. TRIP6 interacts with the ligand binding domain of the thyroid receptor and is predominantly expressed in kidney, liver and lung. It interacts with receptor-interacting protein 2 (RIP2) through LIM domains in a TNF- or IL-1-dependent manner. TRIP6 also interacts with TRAF2, a protein that is crucially involved in TNF signaling, as well as the IL-1 receptor, TLR2 and Nod1. Overexpression of TRIP6 facilitates NFkappaB activation by TNF, IL-1, TLR2 or Nod1, whereas a dominant negative mutant or RNA-interference construct of TRIP6 inhibits NFkappaB activation by TNF, IL-1, TLR2 or Nod1. Moreover, TRIP6 also potentiates RIP2- and Nod1-mediated ERK activation. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBFC |
| WB:1:250~1:1000 FC:1:100~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | MGC10556 antibody MGC10558 antibody MGC29959 antibody MGC3837 antibody MGC4423 antibody OIP-1 antibody OIP1 antibody OPA interacting protein 1 antibody OPA-interacting protein 1 antibody Thyroid hormone receptor interactor 6 antibody Thyroid receptor interacting protein 6 antibody Thyroid receptor-interacting protein 6 antibody TR-interacting protein 6 antibody TRIP-6 antibody Trip6 antibody TRIP6_HUMAN antibody TRIP6i2 antibody ZRP 1 antibody ZRP-1 antibody Zyxin-related protein 1 antibody |
|---|---|
| Molecular Weight(MW) | 50 kDa |
| Cellular Localization | Cytoplasm. Cell junction. Nucleus. |
| SwissProt ID | Q15654 |
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Application
Fig1: Western blot analysis of TRIP6 on human TRIP6 recombinant protein using anti-TRIP6 antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of TRIP6 on K562 (1) and A431 (2) cell lysate using anti-TRIP6 antibody at 1/1,000 dilution.
Application
Fig3: Flow cytometric analysis of K562 cells with TRIP6 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).| Positive Control | Human TRIP6 recombinant protein, K562, A431 cell lysate, K562. |
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| Application Notes | WB:1:250~1:1000 FC:1:100~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide. |
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