NR1B1 antibody Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein antibody Nuclear receptor subfamily 1 group B member 1 antibody Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form antibody RAR alpha antibody RAR antibody RAR-alpha antibody rara antibody RARA_HUMAN antibody RARalpha antibody RARalpha1 antibody Retinoic acid nuclear receptor alpha variant 1 antibody Retinoic acid nuclear receptor alpha variant 2 antibody Retinoic acid receptor alpha antibody Retinoic acid receptor alpha polypeptide antibody
Product description
Retinoids (RA) are metabolites of vitamin A (retinol) that are important signaling molecules during vertebrate development and tissue differentiation. RAs activate the retinoic acid receptor (RAR) and retinoid X receptor (RXR) nuclear transcription factor families. Most retinoid forms activate RAR family members, whereas RXR family members are activated by 9-cis-RA only. RAR family members, which include RARα, RARβ and RARγ, have a high affinity for all transretinoic acids and belong to the same class of nuclear transcription factors as thyroid hormone receptors, vitamin D3 receptor and ecdysone receptor. RAR isoforms are expressed in distinct patterns throughout development and in the mature organism. The human RARα gene maps to chromosome 17 and is implicated in the chromosomal translocation associated with acute promyelocytic leukemia (APL-M3). Specifically, the RARα gene is fused with the promyelocytic leukemia (PML) gene, which encodes the fusion protein PML/RARα. The PML/RARα fusion protein inhibits PML-dependent apoptotic pathways and halts myeloid differentiation at the promyelocytic stage.
Immunogen
recombinant protein
Key Feature
Clonality
Monoclonal
Isotype
IgG
Host Species
Recombinant rabbit
Tested Applications
WBFC
WB:1:1,000 FC:1:50-1:100
Species Reactivity
HumanMouse
Concentration
1mg/ml
Target Information
Alternative Names
NR1B1 antibody Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein antibody Nuclear receptor subfamily 1 group B member 1 antibody Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form antibody RAR alpha antibody RAR antibody RAR-alpha antibody rara antibody RARA_HUMAN antibody RARalpha antibody RARalpha1 antibody Retinoic acid nuclear receptor alpha variant 1 antibody Retinoic acid nuclear receptor alpha variant 2 antibody Retinoic acid receptor alpha antibody Retinoic acid receptor alpha polypeptide antibody
Fig1: Flow cytometric analysis of MCF-7 cells with RAR-alpha antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
Positive Control
MCF-7.
Application Notes
WB:1:1,000 FC:1:50-1:100
Additional Information
Form
Liquid
Storage Instructions
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
