| 存储条件 |
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| Product Name | FANCD2 [SN73-08] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | DKFZp762A223 antibody FA 4 antibody FA D2 antibody FA4 antibody FAC D2 antibody FACD 2 antibody FACD antibody FACD2 antibody FACD2_HUMAN antibody FAD antibody FAD2 antibody FANC D2 antibody FANCD 2 antibody FANCD antibody FANCD2 antibody FANCONI ANEMIA COMPLEMENTATION GROUP D antibody Fanconi anemia complementation group D2 antibody Fanconi anemia group D2 protein antibody FANCONI PANCYTOPENIA TYPE 4 antibody FLJ23826 antibody OTTHUMP00000158853 antibody OTTHUMP00000207925 antibody Protein FACD2 antibody Type 4 Fanconi pancytopenia antibody |
| Product description | Fanconi anemia (FA) is an autosomal recessive disorder character-ized by bone marrow failure, birth defects and chromosomal instability. At the cellular level, FA is characterized by spontaneous chromosomal breakage and a unique hypersensitivity to DNA cross-linking agents. At least 8 complementation groups (A-G) have been identified and 6 FA genes (for subtypes A, C, D2, E, F and G) have been cloned. The FA proteins lack sequence homologies or motifs that could point to a molecular function. Phosphorylation of FANC (Fanconi anemia complementation group) proteins are thought to be important for the function of the FA pathway. Several FA proteins, including FANCA, FANCC, FANCF, and FANCG, interact in a nuclear complex, and this complex is required for the activation (monoubiquitination) of the downstream FANCD2 protein. When monoubiquitinated, the FANCD2 protein co-localizes with the breast cancer susceptibility protein BRCA1 in DNA damage induced foci. In male meiosis, FANCD2 also co-localizes with BRCA1 at synaptonemal complexes. The human FANCD2 gene maps to chromosome 3p25.3, contains 44 exons and encodes a 1,451-amino acid nuclear protein that exists as 2 protein isoforms. |
| Immunogen | recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Recombinant rabbit |
| Tested Applications | WBICC/IFIHCIP |
| WB:1:500-1:1,000 ICC:1:100-1:500 IHC:1:50-1:200 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Unpurified |
| Alternative Names | DKFZp762A223 antibody FA 4 antibody FA D2 antibody FA4 antibody FAC D2 antibody FACD 2 antibody FACD antibody FACD2 antibody FACD2_HUMAN antibody FAD antibody FAD2 antibody FANC D2 antibody FANCD 2 antibody FANCD antibody FANCD2 antibody FANCONI ANEMIA COMPLEMENTATION GROUP D antibody Fanconi anemia complementation group D2 antibody Fanconi anemia group D2 protein antibody FANCONI PANCYTOPENIA TYPE 4 antibody FLJ23826 antibody OTTHUMP00000158853 antibody OTTHUMP00000207925 antibody Protein FACD2 antibody Type 4 Fanconi pancytopenia antibody |
|---|---|
| Molecular Weight(MW) | 166 kDa |
| Cellular Localization | Nucleus, Cytoplasm. |
Application
Fig1: ICC staining FANCD2 in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig2: ICC staining FANCD2 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig3: ICC staining FANCD2 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig4: Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-FANCD2 antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded rat stomach tissue using anti-FANCD2 antibody. Counter stained with hematoxylin.
Application
Fig6: Immunohistochemical analysis of paraffin-embedded rat testis tissue using anti-FANCD2 antibody. Counter stained with hematoxylin.
Application
Fig7: Immunohistochemical analysis of paraffin-embedded mouse stomach tissue using anti-FANCD2 antibody. Counter stained with hematoxylin.| Positive Control | SW480, MCF-7, Hela, rat testis tissue, rat stomach tissue, mouse stomach tissue, mouse testis tissue. |
|---|---|
| Application Notes | WB:1:500-1:1,000 ICC:1:100-1:500 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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