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| Product Name | IL1R1 [D12-D2] |
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| Antibody Type | Primary Antibodies |
| Antigen Alias | Antigen CD121a antibody CD121 antigen-like family member A antibody CD121a antibody CD121a antigen antibody D2S1473 antibody IL 1 antibody IL 1R 1 antibody IL 1R alpha antibody IL 1RT1 antibody IL-1R-1 antibody IL-1R-alpha antibody IL-1RT-1 antibody IL-1RT1 antibody IL1 inhibitor antibody IL1R antibody IL1R1 antibody IL1R1_HUMAN antibody IL1RA antibody IL1RN antibody IL1RT1 antibody Interleukin 1 receptor alpha type 1 antibody Interleukin 1 receptor antagonist protein (IRAP) antibody Interleukin 1 receptor type I antibody Interleukin receptor 1 antibody Interleukin-1 receptor alpha antibody Interleukin-1 receptor type 1 antibody Interleukin-1 receptor type I antibody p80 antibody |
| Product description | Three structurally related ligands for IL-1Rs have been described. These include two agonists, IL-1α and IL-1β, and a specific receptor antagonist, IL-1Rα. Among the activities regulated by IL-1 are fever, acute phase responses, degradation of connective tissue and immunostimulatory activities. The IL-1Rα molecule also binds specifically to IL-1Rs, but fails to initiate intracellular responses. Two distinct IL-1Rs have been identified, each of which belongs to the Ig superfamily and is widely expressed in a broad range of cells and tissues. Although many cell types co-express type I and type II receptors, there is no evidence that these constitute subunits of a single complex. The type II receptor has a short 29 amino acid cytoplasmic domain that does not seem sufficient for signaling while in fact there is considerable evidence arguing that IL-1 signals exclusively through the type I IL-1R. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBFC |
| WB:1:500-1:2,000 FC:1:100-1:200 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | Antigen CD121a antibody CD121 antigen-like family member A antibody CD121a antibody CD121a antigen antibody D2S1473 antibody IL 1 antibody IL 1R 1 antibody IL 1R alpha antibody IL 1RT1 antibody IL-1R-1 antibody IL-1R-alpha antibody IL-1RT-1 antibody IL-1RT1 antibody IL1 inhibitor antibody IL1R antibody IL1R1 antibody IL1R1_HUMAN antibody IL1RA antibody IL1RN antibody IL1RT1 antibody Interleukin 1 receptor alpha type 1 antibody Interleukin 1 receptor antagonist protein (IRAP) antibody Interleukin 1 receptor type I antibody Interleukin receptor 1 antibody Interleukin-1 receptor alpha antibody Interleukin-1 receptor type 1 antibody Interleukin-1 receptor type I antibody p80 antibody |
|---|---|
| Molecular Weight(MW) | 65 kDa |
| Cellular Localization | Membrane, Secreted. |
Application
Fig1: Western blot analysis of IL1R1 on human IL1R1 recombinant protein using anti-IL1R1 antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of IL1R1 on HEK293 (1) and IL1R1-hIgGFc transfected HEK293 (2) cell lysate using anti-IL1R1 antibody at 1/1,000 dilution.
Application
Fig3: Western blot analysis of IL1R1 on ?Hela cells lysate using anti-IL1R1 antibody at 1/1,000 dilution.
Application
Fig4:Flow cytometric analysis of Hela cells with IL1R1 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).| Positive Control | Human IL1R1 recombinant protein, IL1R1-hIgGFc transfected HEK293 cell lysate, ?Hela. |
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| Application Notes | WB:1:500-1:2,000 FC:1:100-1:200 |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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