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| Product Name | ALDH6A1 [B8-H9] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | 1110038I05Rik antibody AI314632 antibody Aldehyde dehydrogenase 6 family member A1 antibody Aldehyde dehydrogenase family 6 member A1 antibody Aldehyde dehydrogenase family 6, subfamily A1 antibody ALDH6A1 antibody Malonate semialdehyde dehydrogenase antibody Malonate-semialdehyde dehydrogenase [acylating] antibody Methylmalonate semialdehyde dehydrogenase [acylating] mitochondrial antibody Methylmalonate-semialdehyde dehydrogenase [acylating] antibody MGC37325 antibody MGC40271 antibody Mitochondrial acylating methylmalonate semialdehyde dehydrogenase antibody mitochondrial antibody MMSA_HUMAN antibody MMSADHA antibody MMSDH antibody |
| Product description | Aldehyde dehydrogenases (ALDHs) mediate the NADP+-dependent oxidation of aldehydes into acids and play an important role in the detoxification of alcohol-derived acetaldehyde, as well as in lipid peroxidation and in the metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH6A1 (aldehyde dehydrogenase family 6 member A1), also known as MMSDH or MMSADHA, is a 535 amino acid mitochondrial protein that belongs to the aldehyde dehydrogenase family. Considered a mitochondrial methylmalonate semialdehyde dehydrogenase, ALDH6A1 catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. It is suggested that ALDH6A1 plays a role in the valine and pyrimidine catabolic pathways. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBICCIHCFC |
| WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:100-1:200 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | 1110038I05Rik antibody AI314632 antibody Aldehyde dehydrogenase 6 family member A1 antibody Aldehyde dehydrogenase family 6 member A1 antibody Aldehyde dehydrogenase family 6 subfamily A1 antibody ALDH6A1 antibody Malonate semialdehyde dehydrogenase antibody Malonate-semialdehyde dehydrogenase [acylating] antibody Methylmalonate semialdehyde dehydrogenase [acylating] mitochondrial antibody Methylmalonate-semialdehyde dehydrogenase [acylating] antibody MGC37325 antibody MGC40271 antibody Mitochondrial acylating methylmalonate semialdehyde dehydrogenase antibody mitochondrial antibody MMSA_HUMAN antibody MMSADHA antibody MMSDH antibody |
|---|---|
| Molecular Weight(MW) | 58 kDa |
| Cellular Localization | Mitochondrion. Nucleoplasm. |
| SwissProt ID | Q02252 |
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Application
Fig1: Western blot analysis of ALDH6A1 on human ALDH6A1 recombinant protein using anti-ALDH6A1 antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of ALDH6A1 on HEK293 (1) and ALDH6A1-hIgGFc transfected HEK293 (2) cell lysate using anti-ALDH6A1 antibody at 1/1,000 dilution.
Application
Fig3: Western blot analysis of ALDH6A1 on different cell lysate using anti-ALDH6A1 antibody at 1/1,000 dilution. Positive control： Lane1: Jurkat Lane2: HEK293 Lane3: Hela Lane4: MCF-7 Lane5: LNcap
Application
Fig4:ICC staining ALDH6A1 (green) and Actin filaments (red) in Hela cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded human ?rectum cancer tissue using anti-ALDH6A1 antibody. Counter stained with hematoxylin.
Application
Fig6: Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissue using anti-ALDH6A1 antibody. Counter stained with hematoxylin.
Application
Fig7:Flow cytometric analysis of Hela cells with ALDH6A1 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).| Positive Control | Human ALDH6A1 recombinant protein, ALDH6A1-hIgGFc transfected HEK293 cell lysate, Jurkat, HEK293, Hela, MCF-7, LNcap, human endometrial cancer tissue, human ?rectum cancer tissue. |
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| Application Notes | WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:100-1:200 |
| Form | Liquid |
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| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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