| 存储条件 |
|---|
| Product Name | C1QC [H9-D7] |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | AI385742 antibody C1Q C antibody C1qc antibody C1QC_HUMAN antibody C1QG antibody Complement C1q subcomponent subunit C antibody Complement component 1, q subcomponent, C chain antibody complement component 1, q subcomponent, gamma polypeptide antibody |
| Product description | C1q, a subcomponent of the classical complement pathway, is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. Six of these subunits are disulfide-linked dimers of chains A and B, while three of these subunits, designated C1q-A through C1q-C, are disulfide-linked dimers of chain C. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drugs as well as cytokines differentially regulate expression of the mRNA, as well as the protein. However, its ability to modulate the interaction of platelets with collagen and immune complexes suggests C1q influences homeostasis as well as other immune activities, and perhaps thrombotic complications resulting from immune injury. Defects in C1q-A, C1q-B and C1q-C cause inactivation of the classical pathway, leading to a rare genetic disorder characterized by lupus-like symptoms. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBFC |
| WB:1:500-1:2,000 FC:1:100-1:200 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | AI385742 antibody C1Q C antibody C1qc antibody C1QC_HUMAN antibody C1QG antibody Complement C1q subcomponent subunit C antibody Complement component 1 q subcomponent C chain antibody complement component 1 q subcomponent gamma polypeptide antibody |
|---|---|
| Molecular Weight(MW) | 25 kDa |
| Cellular Localization | Secreted. |
| SwissProt ID | P02747 |
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Application
Fig1: Western blot analysis of C1QC on human C1QC recombinant protein using anti-C1QC antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of C1QC on HEK293 (1) and C1QC-hIgGFc transfected HEK293 (2) cell lysate using anti-C1QC antibody at 1/1,000 dilution.
Application
Fig3:Flow cytometric analysis of Hela cells with C1QC antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).| Positive Control | Human C1QC recombinant protein, C1QC-hIgGFc transfected HEK293 cell lysate, Hela. |
|---|---|
| Application Notes | WB:1:500-1:2,000 FC:1:100-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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