| 存储条件 |
|---|
| Product Name | TBCC |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Beta tubulin cofactor C antibody CFC antibody TBCC antibody TBCC_HUMAN antibody Tubulin folding cofactor C antibody Tubulin specific chaperone c antibody Tubulin-folding cofactor C antibody Tubulin-specific chaperone C antibody |
| Product description | Microtubules, the primary component of the cytoskeletal network, are highly dynamic structures composed of α/β Tubulin heterodimers. Biosynthesis of functional microtubules involve the participation of several chaperones, termed tubulin folding cofactors A (TBCA), D (TBCD), E (TBCE) and C (TBCC), that act on folding intermediates downstream of the cytosolic chaperonin, alternatively named TCP. TBCC (Tubulin-specific chaperone C), also known as β Tubulin-folding cofactor C or CFC, is a 346 amino acid protein belonging to the TBCD family. Interaction with TBCC causes the release of tubulin polypeptides that are committed to the native state. TBCC shares significant homology with X-linked retinitis pigmentosa 2 gene RP2, in which mutations cause the progressive degeneration of photoreceptor cells. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBIHCICC |
| WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Purification | Unpurified |
| Alternative Names | Beta tubulin cofactor C antibody CFC antibody TBCC antibody TBCC_HUMAN antibody Tubulin folding cofactor C antibody Tubulin specific chaperone c antibody Tubulin-folding cofactor C antibody Tubulin-specific chaperone C antibody |
|---|---|
| Molecular Weight(MW) | 39 kDa |
| Cellular Localization | Cytoplasm. Cytoskeleton. |
| SwissProt ID | Q15814 |
|---|
Application
Fig1: Western blot analysis of TBCC on human TBCC recombinant protein using anti-TBCC antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of TBCC on HEK293 (1) and TBCC-hIgGFc transfected HEK293 (2) cell lysate using anti-TBCC antibody at 1/1,000 dilution.
Application
Fig3: ICC staining TBCC (green) and Actin filaments (red) in Hela cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig4:Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissue using anti-TBCC antibody. Counter stained with hematoxylin.
Application
Fig5: Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissue using anti-TBCC antibody. Counter stained with hematoxylin.| Positive Control | Human TBCC recombinant protein, TBCC-hIgGFc transfected HEK293 cell lysate, Hela, human ovarian cancer tissue, human endometrial cancer tissue. |
|---|---|
| Application Notes | WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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