| 存储条件 |
|---|
| Product Name | THAP1 |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | 4833431A01Rik antibody DYT6 antibody FLJ10477 antibody MGC33014 antibody Nuclear proapoptotic factor antibody THAP 1 antibody THAP domain containing 1 antibody THAP domain containing apoptosis associated protein 1 antibody THAP domain containing protein 1 antibody THAP domain protein 1 antibody THAP domain-containing protein 1 antibody Thap1 antibody THAP1_HUMAN antibody |
| Product description | THAP1 (THAP domain containing, apoptosis associated protein 1) is a 213 amino acid protein that localizes to the nucleoplasm and contains one THAP-type zinc finger, a conserved DNA-binding domain. Interacting with PAR4, THAP1 functions as a pro-apoptotic protein that acts in a zinc-dependent manner and enhances the likelihood of both TNF- and serum withdrawal-induced apoptosis, possibly playing a role in promyelocytic leukemia. The gene encoding THAP1 maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8. |
| Immunogen | Recombinant protein |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WBICCFC |
| WB:1:500-1:2,000 ICC:1:50-1:200 FC:1:50-1:200 | |
| Species Reactivity | Human |
| Concentration | 2mg/ml |
| Alternative Names | 4833431A01Rik antibody DYT6 antibody FLJ10477 antibody MGC33014 antibody Nuclear proapoptotic factor antibody THAP 1 antibody THAP domain containing 1 antibody THAP domain containing apoptosis associated protein 1 antibody THAP domain containing protein 1 antibody THAP domain protein 1 antibody THAP domain-containing protein 1 antibody Thap1 antibody THAP1_HUMAN antibody |
|---|---|
| Molecular Weight(MW) | 25 kDa |
| Cellular Localization | Nucleus. PML body. |
| SwissProt ID | Q9NVV9 |
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Application
Fig1: Western blot analysis of THAP1 on human THAP1 recombinant protein using anti-THAP1 antibody at 1/1,000 dilution.
Application
Fig2: Western blot analysis of THAP1 on HEK293 (1) and THAP1-hIgGFc transfected HEK293 (2) cell lysate using anti-THAP1 antibody at 1/1,000 dilution.
Application
Fig3: ICC staining THAP1 (green) and Actin filaments (red) in Hela cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application
Fig4:Flow cytometric analysis of Jurkat cells with THAP1 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).| Positive Control | Human THAP1 recombinant protein, THAP1-hIgGFc transfected HEK293 cell lysate, Hela, Jurkat. |
|---|---|
| Application Notes | WB:1:500-1:2,000 ICC:1:50-1:200 FC:1:50-1:200 |
| Form | Liquid |
|---|---|
| Storage Instructions | Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles. |
| Storage Buffer | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
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